Dooku1, an analog of Yoda1, is a potent and selective antagonist of the mechanosensitive Piezo1 channel that inhibits endogenous Yoda1-activated channels. Dooku1 inhibits relaxation of relaxation of aorta caused by Yoda1.
potent and selective antagonist of the mechanosensitive Piezo1 channel that inhibits endogenous Yoda1-activated channels
British journal of pharmacology, 175(10), 1744-1759 (2018-03-03)
The mechanosensitive Piezo1 channel has important roles in vascular physiology and disease. Yoda1 is a small-molecule agonist, but the pharmacology of these channels is otherwise limited. Yoda1 analogues were generated by synthetic chemistry. Intracellular Ca2+ and Tl+ measurements were made
Journal of functional biomaterials, 14(3) (2023-03-29)
Exposure to extremely low frequency pulsed electromagnetic fields (ELF-PEMF) is supposed to simulate local EMF generated during mechanical stimulation of bone and may therefore be used to improve bone regeneration. This study aimed at optimizing the exposure strategy and investigating
International journal of cosmetic science, 45(5), 604-611 (2023-05-12)
Throughout our existence, the skin senses and analyses the mechanical forces imposed by the environment. In response to these environmental forces, skin can deform itself and achieve a biological response. The subsequent cutaneous plasticity emerges from mechanical properties arising from
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