SML1797

L67

≥98% (HPLC)

• Sinonimo/i: LigI/III inhibitor L67, N-(3,5-Dibromo-4-methylphenyl)-glycine 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide
• Formula empirica (notazione di Hill): C₁₆H₁₄Br₂N₄O₄
• Numero CAS: 325970-71-6
• Peso molecolare: 486.11
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826071
• NACRES: NA.77
• MDL number: MFCD00363966
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C(N/N=C/C1=CC([N+]([O-])=O)=CC=C1O)CNC2=CC(Br)=C(C)C(Br)=C2
• InChI key: KFEPVFJQVOMODD-IFRROFPPSA-N

Descrizione

Biochem/physiol Actions

L67 is a potent and specific inhibitor of DNA ligase IIIα (LigIIIα) that preferentially targets mitochondrial LigIIIα resulting in mitochondrial dysfunction.

L67 is a potent and specific inhibitor of DNA ligase IIIα (LigIIIα) that preferentially targets mitochondrial LigIIIα resulting in mitochondrial dysfunction. L67 preferentially targets cancer cell mitochondria resulting in enhanced ROS production and caspase 1-dependent apoptosis. L67 in combination with PARP inhibitors decreases survival rate of therapy resistant breast cancer and leukemia cells.

Informazioni sulla sicurezza

• Codici di pericolo: H413
• Avvertenze di sicurezza: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable