SML1371

Prucalopride

≥98% (HPLC), 5-HT4 serotonin receptor agonist, powder

• Sinonimo/i: 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide
• Formula empirica (notazione di Hill): C₁₈H₂₆ClN₃O₃
• Numero CAS: 179474-81-8
• Peso molecolare: 367.87
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Nome del prodotto: Prucalopride, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: COCCCN1CCC(NC(C2=CC(Cl)=C(N)C3=C2OCC3)=O)CC1
• InChI: 1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
• InChI key: ZPMNHBXQOOVQJL-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activity.

Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activity. 5-HT4 receptors are GPCRs that are expressed in the CNS and peripheral tissues. The receptor has a role in GI motility disorders such as irritable bowel syndrome and idiopathic constipation. Agonists are prokinetic and of potential use for disoroders of reduced motility. Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activities. Prucalopride has pK(i) values of 8.60 and 8.10 for the human 5-HT(4a) and 5-HT(4b) receptor, respectively, and at least 290-fold selectivity for 5-HT4 over other serotonin and dopamine receptors.

In healthy male individuals, prucalopride decreases the display of esophageal acid and promotes gastric emptying. It is effective, safe and shows good tolerance for the treatment of men with chronic constipation.

Informazioni sulla sicurezza

• Pittogrammi: GHS07,GHS09
• Parola di avvertenza: Warning
• Codici di pericolo: H315,H319,H335,H400
• Avvertenze di sicurezza: P273 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable