SML1114

IWP-4

≥95% (HPLC)

• Sinonimo/i: N-(6-Methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-acetamide
• Formula empirica (notazione di Hill): C₂₃H₂₀N₄O₃S₃
• Numero CAS: 686772-17-8
• Peso molecolare: 496.62
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825655
• NACRES: NA.77
• eCl@ss: 32160703
• Assay: ≥95% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 0.5 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: O=C1C2=C(CCS2)N=C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)N1C5=C(OC)C=CC=C5
• InChI: 1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
• InChI key: RHUJMHOIQBDFQR-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

IWP-4 is a potent inhbitor of the Wnt pathway regulatory protein porupine (Porcn).

IWP-4 is a potent inhbitor of the Wnt pathway regulatory protein porupine (Porcn). IWP-4 blocks palmitylation, and subsquent secretion and activity of Wnt. IWP-4 induces the differentiation of human pluripotent stem cells into cardiomyocytes.

IWP-4 blocks Wnt family member 5a. It blocks Wnt protein secretion and prevents the canonical and non-canonical signaling pathways.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Parola di avvertenza: Warning
• Codici di pericolo: H302
• Avvertenze di sicurezza: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe di stoccaggio: 11 - Combustible Solids
• WGK: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable