SML0491

Ritonavir

≥98% (HPLC)

• Sinonimo/i: A-84538, ABT-538, Abbott 84538
• Formula empirica (notazione di Hill): C₃₇H₄₈N₆O₅S₂
• Numero CAS: 155213-67-5
• Peso molecolare: 720.94
• Numero MDL: MFCD00927142
• Codice UNSPSC: 12352200
• ID PubChem: 329825441
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 10 mg/mL (clear solution, warmed)
• Temperatura di conservazione: room temp
• Stringa SMILE: O=C(OCC1=CN=CS1)N[C@H]([C@@H](O)C[C@@H](NC([C@@H](NC(N(CC2=CSC(C(C)C)=N2)C)=O)C(C)C)=O)CC3=CC=CC=C3)CC4=CC=CC=C4
• InChI: 1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1; NCDNCNXCDXHOMX-XGKFQTDJSA-N

Descrizione

Applicazioni

Ritonavir has been used:

• as a human immunodeficiency virus (HIV) protease inhibitor to study its effects on placental endocrine function[1]
• as an HIV protease inhibitor to study its effects on reduction of tetrazolium dye in human embryonic kidney cells[2]
• as an organic anion transporting polypeptide (OATP) inhibitor to study its effect on hepatic uptake of bergapten and imperatorin[3]

Azioni biochim/fisiol

Ritonavir is an HIV protease inhibitor now used frequently as a booster of other protease inhbitors. Ritonavir inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. It has also been investigated as a possible anti-cancer agent.

Ritonavir is an HIV protease inhibitor; antiretroviral.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302 + H312 + H332
• Consigli di prudenza: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Classi di pericolo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable