SML0445

Clemastine fumarate salt

≥98% (HPLC)

• Sinonimo/i: (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine
• Formula empirica (notazione di Hill): C₂₁H₂₆ClNO · C₄H₄O₄
• Numero CAS: 14976-57-9
• Peso molecolare: 459.96
• Numero CE: 239-055-2
• Numero MDL: MFCD00137486
• Codice UNSPSC: 12352200
• ID PubChem: 329824727
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Attività ottica: [α]/D +15 to +25°, c = 1 in methanol
• Condizioni di stoccaggio: desiccated
• Colore: white to beige
• Solubilità: DMSO: 5 mg/mL (clear solution; warmed)
• Temperatura di conservazione: room temp
• Stringa SMILE: OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1; PMGQWSIVQFOFOQ-YKVZVUFRSA-N
• Informazioni sul gene: human ... HRH1(3269)

Descrizione

Descrizione generale

Clemastine fumarate is used to treat multiple sclerosis, sneezing and rhinorrhea linked to common cold. It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.

Applicazioni

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.

Azioni biochim/fisiol

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

Caratteristiche e vantaggi

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable