Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

SML0440

Sigma-Aldrich

Spautin-1

≥98% (HPLC)

Sinonimo/i:

6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine, C43

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C15H11F2N3
Numero CAS:
1262888-28-7
Peso molecolare:
271.26
Numero MDL:
MFCD16962292
Codice UNSPSC:
12352200
ID PubChem:
329824722
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to beige

Solubilità

DMSO: 15 mg/mL (clear solution)

Temperatura di conservazione

2-8°C

Stringa SMILE

FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2

InChI

1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
AWIVHRPYFSSVOG-UHFFFAOYSA-N

Applicazioni

Spautin-1 has been used as an autophagy inhibitor:
  • to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model
  • to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin
  • to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay

Azioni biochim/fisiol

Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.
Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.

Pittogrammi

CorrosionExclamation mark
GHS05,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302,H318

Classi di pericolo

Acute Tox. 4 Oral - Eye Dam. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 9

1 of 9

Lys05 ≥98% (HPLC)

Sigma-Aldrich

SML2097

Lys05

Sigma-Aldrich

Sigma-Aldrich

SAE0107

3-Methyladenine Ready made solution

SDF-1 ALPHA human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sigma-Aldrich

SRP3276

SDF-1 ALPHA human

Leupeptin trifluoroacetate salt ≥90% (HPLC), microbial

Sigma-Aldrich

L2023

Leupeptin trifluoroacetate salt

Q-VD-OPh hydrate ≥95% (HPLC)

Sigma-Aldrich

SML0063

Q-VD-OPh hydrate

Bafilomicina A1 ≥90% (HPLC)

Sigma-Aldrich

B1793

Bafilomicina A1

Chloroquine diphosphate salt powder or crystals, 98.5-101.0% (EP)

Sigma-Aldrich

C6628

Chloroquine diphosphate salt

Spautin-1 a quinazolin compound that acts as a specific and potent inhibitor of autophagy

Sigma-Aldrich

567569

Spautin-1

MHY1485 ≥95% (HPLC)

Sigma-Aldrich

SML0810

MHY1485

Dirk Mohn et al.
PloS one, 6(1), e16157-e16157 (2011-01-26)
Peri-implantitis has gained significant clinical attention in recent years. This disease is an inflammatory reaction to microorganisms around dental implants. Due to the limited accessibility, non-invasive antimicrobial strategies are of high interest. An unexpected approach to implant disinfection may evolve
Kuntal Ganguly et al.
Drug delivery, 23(8), 2838-2851 (2015-11-05)
Microspheres of chitosan (CS) cross-linked with polyethylene glycol (PEG) were prepared by emulsion-cross-linking followed by the solvent evaporation technique. The formulations were characterized and subjected to in vitro and in vivo tests to assess cell growth, changes in cell morphology
Yanbin Ma et al.
PloS one, 8(2), e56500-e56500 (2013-02-26)
N-terminally his-tagged human mu opioid receptor, a G protein-coupled receptor was produced in E.coli employing synthetic codon-usage optimized constructs. The receptor was expressed in inclusion bodies and membrane-inserted in different E.coli strains. By optimizing the expression conditions the expression level
Daniel G Panaccione et al.
Scientific reports, 7(1), 8930-8930 (2017-08-23)
Neosartorya fumigata (Aspergillus fumigatus) is the most common cause of invasive aspergillosis, a frequently fatal lung disease primarily affecting immunocompromised individuals. This opportunistic fungal pathogen produces several classes of specialised metabolites including products of a branch of the ergot alkaloid
Alice Verchère et al.
Scientific reports, 2, 306-306 (2012-03-09)
We describe an original activity assay for membrane transport that uses the proton motive force-dependent efflux pump MexAB from Pseudomonas aeruginosa. This pump is co-reconstituted into proteoliposomes together with bacteriorhodopsin (BR), a light-activated proton pump. In this system, upon illumination
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.