SML0307

Pleconaril

≥98% (HPLC), VP1 capsid protein binder, powder

• Sinonimo/i: 3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole, VP 63843, Win 63843
• Formula empirica (notazione di Hill): C₁₈H₁₈F₃N₃O₃
• Numero CAS: 153168-05-9
• Peso molecolare: 381.35
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825312
• NACRES: NA.77
• MDL number: MFCD00923611
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Nome del prodotto: Pleconaril, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥10 mg/mL (warmed)
• storage temp.: room temp
• SMILES string: Cc1cc(CCCOc2c(C)cc(cc2C)-c3noc(n3)C(F)(F)F)on1
• InChI: 1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3
• InChI key: KQOXLKOJHVFTRN-UHFFFAOYSA-N

Descrizione

General description

Pleconaril is a drug, that has antiviral activity.

Application

Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.

Biochem/physiol Actions

Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent that binds to hydrophobic pocket in VP1 major capsid protein. Also, pleconaril delays the onset of diabetes in experimental animals infected with Ljungan virus (LV).

Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent.

Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Parola di avvertenza: Danger
• Codici di pericolo: H301,H413
• Avvertenze di sicurezza: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable