SML0300

Aib-1 trifluoroacetate salt

≥98% (HPLC)

• Sinonimo/i: Tyr-Aib-Trp-Phe trifluoroacetate salt
• Formula empirica (notazione di Hill): C₃₃H₃₇N₅O₆ · xC₂HF₃O₂
• Numero CAS: 1334763-90-4
• Peso molecolare: 599.68 (free base basis)
• Codice UNSPSC: 12352202
• ID PubChem: 329825306
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: lyophilized solid
• Colore: white to beige
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC(=O)C(F)(F)F.CC(C)(NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc2cc3ccccc3[nH]2)C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C33H37N5O6.C2HF3O2/c1-33(2,38-29(40)25(34)16-21-12-14-24(39)15-13-21)32(44)37-27(19-23-18-22-10-6-7-11-26(22)35-23)30(41)36-28(31(42)43)17-20-8-4-3-5-9-20;3-2(4,5)1(6)7/h3-15,18,25,27-28,35,39H,16-17,19,34H2,1-2H3,(H,36,41)(H,37,44)(H,38,40)(H,42,43);(H,6,7)/t25-,27-,28-;/m0./s1; NELSAMPJZPTPEG-MDQBHWJISA-N

Descrizione

Azioni biochim/fisiol

Aib-1 is an inhibitor of β-Amyloid oligomerization.

Aib-1 is an inhibitor of β-Amyloid oligomerization. Aib-1 is an endomorphin analog more stable to enzymatic degradation and incorporating the β-breaker 2 aminoisobutyric acid. It interacted with Aβ and markedly inhibited the formation of toxic oligomer and fibril growth using in vitro assays, prevented Aβ toxicity in neuronal PC12 cells, and increased longevity in a fly model of Alzheimer′s disease. Aib-1 activity is thought to be due to multi-mode interactions including aromatic, hydrophobic, and polar contacts with Aβ.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable