SCP0141
ET A Receptor Antagonist JKC 301
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About This Item
Formula empirica (notazione di Hill):
C32H44N6O7
Peso molecolare:
624.73
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
![(2R)-2-[[(2R)-2-([(2S)-2-[(1-AZEPANYLCARBONYL)AMINO]-4-METHYLPENTANOYL]AMINO)-3-(1-METHYL-1H-INDOL-3-YL)PROPANOYL]AMINO]-3-(2-PYRIDINYL)PROPANOIC ACID AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/603/815/df767102-f4fb-4cb9-86d8-c9c28f9f88fa/640/df767102-f4fb-4cb9-86d8-c9c28f9f88fa.png)
Saggio
≥95% (HPLC)
Forma fisica
lyophilized
Composizione
Peptide Content, ≥85%
Condizioni di stoccaggio
protect from light
Temperatura di conservazione
−20°C
Amino Acid Sequence
Asp-Pro-Ile-Leu-Trp
Applicazioni
JKC-301 (Asp-Pro-Ile-Leu-Trp) is a pentapeptide used as an selective endothelin ET(A) receptor antagonist.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
J E Tanus-Santos et al.
European journal of pharmacology, 396(1), 33-37 (2000-05-24)
The increased endothelin-1 levels observed after smoking may result from nicotine-stimulated endothelin-1 production by endothelial cells. In this study, we investigated the effects of selective endothelin ET(A) receptors antagonist Cycle D-a-aspartyl-L-prolyl-D-isoleucyl-D-tryptophyl (JKC 301) and of endothelin ET(B) receptors antagonist N-cis-2
L C Ngoka et al.
Journal of mass spectrometry : JMS, 35(2), 265-276 (2000-02-19)
We previously showed by using mass spectrometry that endothelin A selective receptor antagonists BQ123 and JKC301 form novel coordination compounds with sodium ions. This property may underlie the ability of an ET(A) antagonist to induce net tubular sodium reabsorption in
Z Fekete et al.
The Journal of pharmacology and experimental therapeutics, 275(1), 215-218 (1995-10-01)
In this study we characterized the endothelin (ET) receptors of cultured L6 myotubes in order to gain a further insight into the mechanism of the ET effect on skeletal muscle cells. Displacements of 125I-ET-1 by unlabeled ET-1, ET-2 and ET-3
Daphne Merkus et al.
American journal of physiology. Heart and circulatory physiology, 288(5), H2088-H2092 (2005-01-08)
Alpha-adrenergic vasoconstriction in the coronary circulation is mediated through alpha-adrenoceptors on cardiac myocytes and subsequent release of endothelin, a very potent, long-lasting vasoconstrictor. Recent studies found that adult cardiac myocytes do not express the preproendothelin gene. Thus we hypothesized that
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