SAB5701115

Anti-PD-L1/CD274 antibody produced in mouse

• Codice UNSPSC: 12352203
• NACRES: NA.43

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Tipo di anticorpo: primary antibodies
• Clone: monoclonal
• Forma fisica: liquid
• Reattività contro le specie: rat, mouse, monkey, human
• Concentrazione: 1.51 mg/mL
• tecniche: immunohistochemistry: 1:50-1:100; immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• N° accesso UniProt: Q9NZQ7
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... PD-L1(29126)

Descrizione

Descrizione generale

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Immunogeno

Recombinant protein of human PD‐L1 extracellular domain.

Stato fisico

Tris Buffer, pH7.3-7.7, with 1% BSA and <0.1% Sodium azide.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable