SAB5700286

Anti-Phospho-CHEK1-S280 antibody produced in rabbit

• Sinonimo/i: CHEK1, CHK1
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: 43; 50; 54
• Reattività contro le specie: mouse, human, rat
• Concentrazione: 1.66 mg/ml
• tecniche: immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200; western blot: 1:200-1:2000
• N° accesso UniProt: O14757
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pSer280)
• Informazioni sul gene: human ... CHEK1(1111)

Descrizione

Descrizione generale

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Immunogeno

A synthetic phosphorylated peptide around S280 of human CHEK1 (NP_001265.2).

Stato fisico

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Stoccaggio e stabilità

Store at -20℃. Avoid freeze / thaw cycles.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable