SAB4702130

Monoclonal Anti-CD22, purified produced in mouse

• Sinonimo/i: SIGLEC-2, SIGLEC2
• Codice UNSPSC: 12352203

Proprietà

• Coniugato: unconjugated
• Livello qualitativo: 100
• Tipo di anticorpo: primary antibodies
• Clone: S-HCL-1, monoclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• Concentrazione: 1 mg/ml
• tecniche: flow cytometry: suitable
• Isotipo: IgG2bκ
• N° accesso UniProt: P20273
• Temperatura di conservazione: 2-8°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CD22(933)

Descrizione

Descrizione generale

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Specificità

The mouse monoclonal antibody S-HCL-1 (also known as S-HCL1) recognizes an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.

Immunogeno

Whole hairy cell leukemia cells and membrane preparation

Stato fisico

Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Nota sulla preparazione

Purified by protein-A affinity chromatography.

Stoccaggio e stabilità

Store at 2-8°C. Do not freeze.

Altre note

The antibody solution should be gently mixed before use.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable