SAB4702100

Monoclonal Anti-Myeloperoxidase PE produced in mouse

• Sinonimo/i: MPO
• Codice UNSPSC: 12352203

Proprietà

• Coniugato: phycoerythrin (R-PE) conjugate
• Livello qualitativo: 100
• Tipo di anticorpo: primary antibodies
• Clone: MPO421-8B2, monoclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• tecniche: flow cytometry: suitable
• Isotipo: IgG1
• N° accesso UniProt: P05164
• Temperatura di conservazione: 2-8°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... MPO(4353)

Descrizione

Descrizione generale

Myeloperoxidase (MPO) is a heme enzyme that is localized in azurophilic (primary) granules of myeloid cells and its synthesis occurs at an early stage of differentiation. The mature myeloperoxidase is a tetramer composed of two light (12 kDa) and two heavy (60 kDa) chains. This enzyme uses hydrogen peroxide to oxidize numerous substrates, including serotonin, melatonin or chloride, to produce reactive free radicals that contribute to immune reactions of myeloid cells against pathogens. Myeloperoxidase functions not only in host defense by mediating efficient microbial killing but also can contribute to progressive tissue damage in chronic inflammatory states such as atherosclerosis or acute pancreatitis.

Specificità

The mouse monoclonal antibody MPO421-8B2 recognizes human myeloperoxidase, a heme protein present in intracellular granules of myeloblasts, neutrophils and monocytes. It is a marker of acute myelogenous leukemias and acute lymphoblastic leukemias.

Immunogeno

Human myeloperoxidase

Stato fisico

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota sulla preparazione

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Stoccaggio e stabilità

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Altre note

The antibody solution should be gently mixed before use.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable