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SAB4504450

Sigma-Aldrich

Anti-phospho-SAPK/JNK (pTyr185) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-JNK, Anti-JNK-46, Anti-JNK1, Anti-JNK1A2, Anti-JNK21B1/2, Anti-PRKM8, Anti-SAPK1, Anti-SAPK1c

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 48 kDa

Reattività contro le specie

mouse, rat, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

P45983
P45984
P53779

N° accesso UniProt

P45983

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

phosphorylation (pTyr185)

Informazioni sul gene

human ... MAPK10(5602) , MAPK8(5599) , MAPK9(5601)

Descrizione generale

MAPK9 (mitogen-activated protein kinase 9)/JNK2 (C-Jun N-terminal kinase 2)/ stress-activated protein kinase 2 (SAPK2) spans around 58494bp. The JNK2 gene is located on human chromosome 5q35. It has 17 introns.

Immunogeno

The antiserum was produced against synthesized peptide derived from human SAPK/JNK around the phosphorylation site of Tyr185.

Immunogen Range: 151-200

Azioni biochim/fisiol

Stress-activated protein kinase 2 (SAPK2) participates in proliferation, differentiation, apoptosis, migration, transcriptional regulation and development. It controls the cellular acidic/lysosomal cellular compartment. JNK2 plays an important role in mediating stress-induced apoptosis and modulating gene expression.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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JNK2 is activated during ER stress and promotes cell survival
Raciti M, et al.
Cell Death & Disease (2012)
MAPK9 (mitogen-activated protein kinase 9)
Chen F
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2003)
Junhui Liu et al.
Annals of translational medicine, 9(3), 260-260 (2021-03-13)
Kiaa0101, a regulator of cell proliferation, is overexpressed in many malignant tumors. However, its role in promoting invasion of glioma is poorly understood. Here, we investigated the effects of Kiaa0101 on glioma invasion and elucidated the underlying mechanisms of action.
Chin-Feng Hsuan et al.
Molecules (Basel, Switzerland), 25(24) (2020-12-17)
The proliferation and migration of vascular smooth muscle cells (VSMCs) are essential in the pathogenesis of various vascular diseases, such as atherosclerosis and restenosis. Among the mediators of VSMC during atherosclerosis development, platelet-derived growth factor (PDGF)-BB is a potent mitogen

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.