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Key Documents

SAB4503717

Sigma-Aldrich

Anti-MED24 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Mediator complex subunit 24, Mediator of RNA polymerase II transcription subunit 24, Thyroid hormone receptor-associated protein 4, Trap100, hTRAP100

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 110 kDa

Reattività contro le specie

human, mouse, rat

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... MED24(9862)

Descrizione generale

Mediator complex subunit 24 (MED24), also known as thyroid hormone receptor associated protein 100 (TRAP100), is encoded by the gene mapped to human chromosome 17q21.1. The protein is ubiquitously expressed in human tissues, but at high level in skeletal muscle, heart, and placenta. TRAP100 is characterized with a notional zinc finger at N-terminal, a putative ATP/GTP binding site in the central region, and six dispersed LXXLL motifs.

Immunogeno

The antiserum was produced against synthesized peptide derived from human MED24.

Immunogen Range: 801-850

Applicazioni

Anti-MED24, C-Terminal antibody produced in rabbit has been used in immunohistochemistry.

Azioni biochim/fisiol

Mediator complex subunit 24 (MED24)/ thyroid hormone receptor associated protein 100 (TRAP100), which is a subunit of TRAP coactivator complex, might promote TRAP-mediated enhancement of nuclear receptor - signaling pathways. The MED1/MED24 complex plays an essential role in the pubertal mammary gland development and growth of breast carcinoma cells via the rat sarcoma (RAS)-mitogen-activated protein kinase (MAPK) pathway. The MED1/MED24 complex is over-expressed in female breast cancer (FBC). In Drosophila, mutation of gene encoding MED24 inhibit salivary gland cell death, caspase activation, and the breakdown of nuclear lamins.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Pascal Jézéquel et al.
Database : the journal of biological databases and curation, 2013, bas060-bas060 (2013-01-18)
We recently developed a user-friendly web-based application called bc-GenExMiner (http://bcgenex.centregauducheau.fr), which offered the possibility to evaluate prognostic informativity of genes in breast cancer by means of a 'prognostic module'. In this study, we develop a new module called 'correlation module'
Miangela M Lacle et al.
Cellular oncology (Dordrecht), 38(3), 237-245 (2015-04-24)
Overall, HER2-amplified female breast cancer (FBC) is associated with a high grade, an aggressive phenotype and a poor prognosis. In male breast cancer (MBC) amplification of HER2, located on chromosome 17, occurs at a lower frequency than in FBC, where
Lei Wang et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 239(3), 954-964 (2010-01-12)
The steroid hormone ecdysone triggers the rapid destruction of larval tissues through transcriptional cascades that culminate in rpr and hid expression and caspase activation. Here, we show that mutations in Mdh2 and Med24 block caspase cleavage and larval salivary gland
C X Yuan et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(14), 7939-7944 (1998-07-08)
Cognate cDNAs are described for 2 of the 10 thyroid hormone receptor-associated proteins (TRAPs) that are immunopurified with thyroid hormone receptor alpha (TRalpha) from ligand-treated HeLa (alpha-2) cells. Both TRAP220 and TRAP100 contain LXXLL domains found in other nuclear receptor-interacting
J Zhang et al.
Molecular endocrinology (Baltimore, Md.), 13(7), 1130-1140 (1999-07-16)
Nuclear hormone receptors (NRs) regulate transcription in part by recruiting distinct transcriptional coregulatory complexes to target gene promoters. The thyroid hormone receptor (TR) was recently purified from thyroid hormone-cultured HeLa cells in association with a complex of novel nuclear proteins

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