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Key Documents

SAB4502007

Sigma-Aldrich

Anti-NKTR antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

NK-TR protein, NK-tumor recognition protein, Natural-killer cells cyclophilin-related protein

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 165 kDa

Reattività contro le specie

human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

N° accesso NCBI

P30414

N° accesso UniProt

P30414

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... NKTR(4820)

Categorie correlate

Descrizione generale

NKTR (Natural killer-tumor recognition sequence) is a 150kDa subunit of a putative tumor-recognition complex. It is expressed on the surface of natural killer cells. It contains an amino-terminal hydrophobic region, a cyclophilin-related domain, three histone-like domains, and three arginine and serine-rich domains.

Immunogeno

The antiserum was produced against synthesized peptide derived from human NKTR.

Immunogen Range: 784-833

Applicazioni

Anti-NKTR antibody produced in rabbit is suitable for immunohistochemistry and indirect immunofluorescence studies.

Azioni biochim/fisiol

NKTR (Natural killer-tumor recognition sequence) plays an important role in NK-cell cytotoxicity in human T-cells. It participates in identifying as well as NK-like killing. It has been reported that IL2 (interleukin 2) control the NKTR activity by altering the RNA splicing pattern.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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S K Anderson et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(2), 542-546 (1993-01-15)
Natural killer cells are non-major histocompatibility complex-restricted large granular lymphocytes that can recognize and destroy tumor cells without prior stimulation. A 150-kDa molecule on the surface of human natural killer cells was identified as a component of a putative tumor-recognition
C A Chambers et al.
Journal of immunology (Baltimore, Md. : 1950), 152(6), 2669-2674 (1994-03-15)
NK cells lyse target cells without previous immune sensitization. A small subset of T cells also exhibits NK-like activity, which is distinct from TCR-mediated, MHC-restricted, and MHC-unrestricted cytotoxicity. We recently cloned a gene, NK-TR, which is postulated to be part
A Rinfret et al.
Molecular immunology, 30(14), 1307-1313 (1993-10-01)
We have recently isolated and characterized human and mouse genes of a putative natural killer (NK) cell tumour-recognition protein (NK-TR) that is specifically expressed in NK cells. This gene codes for a 150 kD protein with a cyclophilin-related amino terminus

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