SAB4300204

Anti-phospho-SNCA (pTyr¹²⁵) antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: Anti-MGC110988 antibody produced in rabbit, Anti-NACP antibody produced in rabbit, Anti-PARK1 antibody produced in rabbit, Anti-PARK4 antibody produced in rabbit, Anti-synuclein, alpha (non A4 component of amyloid precursor) antibody produced in rabbit
• Numero MDL: MFCD02095740
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: ~18 kDa
• Reattività contro le specie: human
• Concentrazione: 1 mg/mL
• tecniche: indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotipo: IgG
• Sequenza immunogenica: (E-A-YP-E-M)
• N° accesso NCBI: NP_000336.1
• N° accesso UniProt: P37840
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pTyr125)
• Informazioni sul gene: human ... SNCA(6622)

Descrizione

Immunogeno

Peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y(p)-E-M), according to the protein SNCA.

Caratteristiche e vantaggi

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Descrizione del bersaglio

SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons.

Stato fisico

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable