SAB4300056

Anti-phospho-PGR (pSer¹⁹⁰) antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: Anti-NR3C3 antibody produced in rabbit, Anti-PR antibody produced in rabbit, Anti-progesterone receptor antibody produced in rabbit
• Numero MDL: MFCD00239723
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: ~99 kDa
• Reattività contro le specie: human
• Concentrazione: 1 mg/mL
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotipo: IgG
• Sequenza immunogenica: (G-L-SP-P-A)
• N° accesso NCBI: NP_000917.3
• N° accesso UniProt: P06401
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pSer190)
• Informazioni sul gene: human ... PGR(5241)

Descrizione

Immunogeno

Peptide sequence around phosphorylation site of serine 190 (G-L-S(p)-P-A), according to the protein PGR.

Caratteristiche e vantaggi

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Descrizione del bersaglio

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

Stato fisico

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable