SAB4200268

Anti-Tensin 2 (C-terminal) antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: Anti-C1TEN, Anti-TENC1, Anti-TNS2
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• PM: antigen ~160 kDa
• Reattività contro le specie: human
• Convalida avanzata: recombinant expression; Learn more about Antibody Enhanced Validation
• Concentrazione: ~1.5 mg/mL
• tecniche: western blot: 1.5-3.0 μg/mL using HEK-293T cells over expressing human tensin 2.
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TENC1(23371)

Descrizione

Descrizione generale

Tensin 2 belongs to the Tensin family. It shares extensive homology with tensin1 at its N- and C-terminals, including the actin-binding domain, the Src Homology 2 (SH2) and c domains. Tensin 2 mRNA is highly expressed in heart, kidney, skeletal muscle and liver.

Immunogeno

synthetic peptide corresponding to a sequence located near the C-terminus human tensin 2 (GeneID: 23371), conjugated to KLH. The corresponding sequence is identical in human tensin 2 isoforms 2 and 3, and highly conserved (single amino acid substitution) in mouse tensin 2.

Applicazioni

Anti-Tensin 2 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.

Azioni biochim/fisiol

Tensin 2 interacts with several binding partners through its Src Homology 2 (SH2)-phosphotyrosine binding (PTB) domains, including Axl receptor tyrosine kinase (RTK), caveolin-1 and with the tumor suppressor gene deleted in liver cancer 1 (DLC1) to regulate DLC1 tumor suppressor activity. Tensin 2 also inhibits Akt signaling and cell survival. It reduces intracellular PtdIns(3,4,5)P₃ levels at the plasma membrane. It modulates cytoskeletal dynamics and impacts phosphoinositide-Akt signaling through its PTPase domain. Tensin 2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma (HCC).

Stato fisico

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable