SAB4200160

Anti-Synaptotagmin 7 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinonimo/i: Anti-IPCA-7, Anti-PCANAP7, Anti-SYT-VII, Anti-SYT7
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: ~45 kDa
• Reattività contro le specie: mouse, human
• Convalida avanzata: recombinant expression; Learn more about Antibody Enhanced Validation
• Concentrazione: ~1.0 mg/mL
• tecniche: western blot: 1-2 μg/mL using mouse brain extracts (S1 fraction) and HEK-293T cell lysates expressing human synaptotagmin 7
• N° accesso UniProt: O43581
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... SYT7(9066) ; mouse ... Syt7(54525)

Descrizione

Descrizione generale

Synaptotagmin 7, also known as Syt7, is a transmembrane Ca²⁺ binding protein. It belongs to synaptotagmin family of proteins. Syt7 contains a single transmembrane domain, a variable linker sequence and C2A and C2B Ca²⁺-binding domains. Syt7 is ubiquitously expressed during development but is later restricted to dividing cells, postmitotic neurons and neuroendocrine cells.

Applicazioni

Anti-Synaptotagmin 7 antibody produced in rabbit has been used in immunoblotting.

Azioni biochim/fisiol

Synaptotagmins regulates membrane or vesicular trafficking, including synaptic vesicle (SV) exocytosis. Synaptotagmin 7 plays a vital role in regulation of Ca²⁺-dependent lysosome exocytosis. Syt7 is expressed in pancreatic β-cells and has been suggested to function as a Ca²⁺ sensor regulating insulin secretion. Knockout of Syt7 in mice results in impaired insulin secretion and glucose intolerance.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable