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SAB2501514

Sigma-Aldrich

Anti-KLHL6 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-FLJ00029, Anti-kelch-like 6, Kelch-like 6 (Drosophila), Kelch-like protein KLHL6

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

goat

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

rat, canine, human, mouse

tecniche

indirect ELISA: suitable
western blot: suitable

N° accesso UniProt

Q8WZ60

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... KLHL6(89857)

Descrizione generale

Kelch-like protein 6 (KLHL6) is a member of BTB (broad-complex, tramtrack and bric à brac)-kelch protein family. The gene encoding this protein is mapped to human chromosome 3q27. The encoded protein expression is confined to lymphoid tissue. KLHL6 exhibits high activity within the germinal center of B cells. The protein structure consists of a BTB domain at N terminal and six kelch repeats at the C terminal. KLHL6 protein is primarily expressed in human tonsil B lymphocytes.
Kelch-like protein 6 (KLHL6) plays a vital role in B-cell receptor (BCR) cell signaling and differentiation pathway of germinal center within B- cells. Aberration in the expression of this protein leads to chronic lymphocytic leukemia (CLL).

Immunogeno

Peptide with sequence SERTKPRMHEFQSE, from the internal region of the protein sequence according to NP_569713.2

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Update on the Kelch-like (KLHL) gene family.
Dhanoa BS
Human Genomics (2013)
Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells.
Gupta-Rossi N
Molecular Immunology (2003)
An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.
Sharma PR
Endocrinology (2015)
The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation.
Kroll J
Molecular and Cellular Biology (2005)
Mandeep Singh et al.
Cell, 180(5), 878-894 (2020-02-16)
Pathogenic autoantibodies arise in many autoimmune diseases, but it is not understood how the cells making them evade immune checkpoints. Here, single-cell multi-omics analysis demonstrates a shared mechanism with lymphoid malignancy in the formation of public rheumatoid factor autoantibodies responsible

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