Documenti fondamentali

Visualizza tutta la documentazione

Vai a

S9263

Swainsonine

Name: Swainsonine
Brand: SIGMA

solid, ≥99% (HPLC)

Sinonimo/i:

(1S,2R,8R,8aR)-1,2,8-Octahydroindolizidinetriol

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₈H₁₅NO₃

Numero CAS:

72741-87-8

Peso molecolare:

173.21

NACRES:

NA.32

PubChem Substance ID:

24899832

UNSPSC Code:

12352210

MDL number:

MFCD00017554

Beilstein/REAXYS Number:

4175740

Questo prodotto non è più disponibile. Contatta l'Assistenza Tecnicaper chiedere aiuto

Proprietà

Nome del prodotto

Swainsonine, synthetic

biological source

synthetic

Quality Segment

200

assay

≥95% (HPLC)

form

solid

solubility

methanol: 5 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

O[C@@H]1CCCN2C[C@@H](O)[C@@H](O)C12

InChI

1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7?,8-/m1/s1

InChI key

FXUAIOOAOAVCGD-DCDLSZRSSA-N

Descrizione

General description

Swainsonine is produced by endophytes, plant and insect pathogens. It is synthesized from the pipecolic acid and mevalonic acid. Swainsonine is a water-soluble indole alkaloid.

Application

Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II. It inhibits glycoprotein processing and also acts as immune modulator.

Swainsonine has been used:

to test its effect on neural stem cell proliferation
to inhibit α-mannosidase in TC-1 tumor cells
to inhibit β1,6-branching synthesis in hepatocellular carcinoma (HCC) cells

Biochem/physiol Actions

Swainsonine is an inhibitor of α-mannosidase in endoplasmic reticulum and Golgi apparatus. It also activates the natural killer cells. Swainsonine elicits neurologic toxicity and its exposure impairs learning and memory resulting in cognitive deficit. It inhibits hepatocellular carcinoma and sensitizes them to respond to anti-cancer drug paclitaxel.[1]

Confronta articoli simili

Visualizza il confronto per intero

Mostra le differenze

1 of 1

Questo articolo	S8195	574775-M	218775
Sigma-Aldrich S9263 Swainsonine	Sigma-Aldrich S8195 Swainsonine	Sigma-Aldrich 574775-M Swainsonine, Swainsona canescens	Sigma-Aldrich 218775 Castanospermine, Castanospermum australe
assay ≥95% (HPLC)	assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥98% (TLC)
biological source synthetic	biological source Metarrhizium anisopliae	biological source -	biological source -
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
form solid	form lyophilized powder	form solid	form solid
solubility methanol: 5 mg/mL, clear, colorless to light yellow	solubility H₂O: soluble 1 mg/mL	solubility water: 1 mg/mL, DMSO: 5 mg/mL, chloroform: soluble	solubility water: 1 mg/mL
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

Still not finding the right product?

Explore all of our products under Swainsonine

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documenti section.

Se ti serve aiuto, non esitare a contattarci Servizio Clienti

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.