R4282

RF9 trifluoroacetate salt

≥97% (HPLC)

• Sinonimo/i: 1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt
• Formula empirica (notazione di Hill): C₂₆H₃₈N₆O₃ · xC₂HF₃O₂
• Numero CAS: 876310-60-0
• Peso molecolare: 482.62 (free base basis)
• Codice UNSPSC: 12352200
• ID PubChem: 329824030
• NACRES: NA.77

Proprietà

• Saggio: ≥97% (HPLC)
• Solubilità: H₂O: 20 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC(=O)C(F)(F)F.NC(=N)NCCC[C@H](NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
• InChI: 1S/C26H38N6O3.C2HF3O2/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26;3-2(4,5)1(6)7/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30);(H,6,7)/t17-,18+,19-,20-,21-,26-;/m0./s1; GPVFYPYIOXHDCU-CFIUKZCSSA-N

Descrizione

Azioni biochim/fisiol

RF9 is a neuropeptide FF receptor antagonist.

RF9 is a neuropeptide FF receptor antagonist. NPFF is a member of the FMRFamide (Phe-Met-Arg-PheNH2) family of neuropeptides, which are implicated in nociception and regulation of opioid analgesia. NPFF exhibits antiopioid activity (hyperalgesia). NPFF antagonists are expected to improve the therapeutic efficacy of opioids for treatment of chronic pain. The affinity of RF9 for NPFF1R and NPFF2R is 58 and 75 nM, respectively. RF9 acts as a potent competitive antagonist of NPFF at NPFF2R RF9 exhibits no agonist activity in GTPgS assays.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)