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PRS2221

Sigma-Aldrich

Anti-BAFF antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-BLyS, Anti-Tall, Anti-Thank, Anti-Tumor necrosis factor (ligand) superfamily, member 13b

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

predicted mol wt 31 kDa

Reattività contro le specie

human, rat, mouse

tecniche

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

Descrizione generale

B-lymphocyte activating factor (BAFF/TNFSF13B) is a cytokine that belongs to the TNF (tumor necrosis factor) superfamily. BAFF is located on human chromosome 13q33.

Immunogeno

a peptide corresponding to amino acids near the carboxy-terminus of human BAFF.

Azioni biochim/fisiol

B cell activating factor (BAFF) participates in B cell and T cell mediated immunity. It plays a key role in the survival and differentiation of B cells. Mutations in BAFF regulates the levels of antibody. BAFF also participates in enhancing the responses of IL-6 (interlukin-6) and TNF-α (tumor necrosis factor alpha), that helps hepatocytes in the production of acute-phase protein.

Linkage

The action of this antibody can be blocked using blocking peptide SBP2221.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Polymorphism in the 5′ regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome.
Nossent JC, et al.
Rheumatology (Basel), 47(9), 1311-1316 (2008)
B cell-activating factor regulates the survival of B lymphocytes infected with human cytomegalovirus.
Xu H, et al.
Immunology Letters, 187, 1-6 (2017)
Association of genetic variation in B-cell activating factor with chronic hepatitis B virus infection.
Han Q, et al.
Immunology Letters, 188, 53-58 (2017)
Increased levels of BAFF in patients with systemic lupus erythematosus are associated with acute-phase reactants, independent of BAFF genetics: a case?control study.
Eilertsen G?, et al.
Rheumatology (Basel), 50(12), 2197-2205 (2011)
Sung-Sik Yoon et al.
International journal of molecular sciences, 22(13) (2021-07-21)
Fibroblast-like synoviocytes (FLSs) play a key role in the pathogenesis of rheumatoid arthritis (RA) by producing inflammatory cytokines and interacting with various immune cells, which contribute to cartilage destruction. RA-FLSs activated by tumor necrosis factor alpha (TNF-α), exacerbate joint damage

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