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P9178

Prochlorperazine dimaleate salt

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A voi/SKUDisponibilitàPrezzo
5 g
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59,10 €

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C20H24ClN3S · 2C4H4O4
Numero CAS:
84-02-6
Peso molecolare:
606.09
NACRES:
NA.77
PubChem Substance ID:
57654570
UNSPSC Code:
41116107
EC Number:
201-511-3
MDL number:
MFCD00069330
Form:
powder

59,10 €

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form

powder

Quality Segment

200

solubility

H2O: slightly soluble 0.3 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.3 mg/mL, methanol: soluble

originator

GlaxoSmithKline

SMILES string

OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1

InChI

1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

InChI key

DSKIOWHQLUWFLG-SPIKMXEPSA-N

Gene Information

human ... DRD2(1813)

Biochem/physiol Actions

Prochlorperazine is an anti-nausea and neuroleptic agent. It is known to cause neuropsychiatric side effects. Prochlorperazine inhibits the action of dopamine in the central nervous system. It acts as an antiemetic drug and prevents vomiting and stimulates sleep. Prochlorperazine is useful as a tranquilizer in the treatment of schizophrenia and nonpsychotic anxiety.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist; antispasmodic

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Questo articolo
H127C4024H1512
Prochlorperazine dimaleate salt

Sigma-Aldrich

P9178

Prochlorperazine dimaleate salt

p-Fluorohexahydro-sila-difenidol hydrochloride powder, ≥98% (HPLC)

Sigma-Aldrich

H127

p-Fluorohexahydro-sila-difenidol hydrochloride

Carbamazepine powder

Sigma-Aldrich

C4024

Carbamazepine

Haloperidol powder

Sigma-Aldrich

H1512

Haloperidol

description

-

description

powder, ≥98% (HPLC)

description

powder

description

powder

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.3 mg/mL, H2O: slightly soluble 0.3 mg/mL, methanol: soluble

solubility

ethanol: soluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL, H2O: slightly soluble 1.5 mg/mL

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 29 mg/mL, ethanol: soluble, propylene glycol: soluble, H2O: insoluble

solubility

DMSO: soluble, 0.1 M HCl: 3 mg/mL, H2O: insoluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL, ethanol: soluble

originator

GlaxoSmithKline

originator

-

originator

Novartis

originator

Johnson & Johnson

Gene Information

human ... DRD2(1813)

Gene Information

human ... CHRM3(1131)

Gene Information

human ... BZRAP1(9256), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), PRNP(5621), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scn2a1(24766), Scnn1a(25122), Scnn1g(24768), Slc6a1(79212)

Gene Information

human ... ABCB1(5243), ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), EBP(10682), HRH1(3269), HTR2A(3356), HTR2C(3358), HTR7(3363), KCNH1(3756), KCNH2(3757), PRNP(5621)
rat ... Adra1a(29412), Adra2a(25083), Chrm1(25229), Chrm2(81645), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2c(25187), Oprs1(29336), Slc6a3(24898), Slc6a4(25553)

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Lact. - Repr. 2 - STOT SE 3

target_organs

Central nervous system

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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