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P7908

Sigma-Aldrich

N-(1-Pyrenyl)maleimide

Sinonimo/i:

1-(1-Pyrenyl)-1H-pyrrole-2,5-dione

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About This Item

Formula empirica (notazione di Hill):
C20H11NO2
Numero CAS:
42189-56-0
Peso molecolare:
297.31
Beilstein:
1542661
Numero CE:
255-702-1
Numero MDL:
MFCD00049301
Codice UNSPSC:
12352100
ID PubChem:
24898892
NACRES:
NA.22

Forma fisica

powder

Punto di fusione

235-237 °C (lit.)

Stringa SMILE

O=C1C=CC(=O)N1c2ccc3ccc4cccc5ccc2c3c45

InChI

1S/C20H11NO2/c22-17-10-11-18(23)21(17)16-9-7-14-5-4-12-2-1-3-13-6-8-15(16)20(14)19(12)13/h1-11H
YXKWRQLPBHVBRP-UHFFFAOYSA-N

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Categorie correlate

Applicazioni

Reactant used in synthesis of:
  • Oligodeoxynucleotide derivatives
  • Polymer conjugates of immunogenic peptides
  • Modified oligonucleotides for biosensing applications,

Reactant:
  • Involved in synthesis of thermally stable fluorescent maleimide/isobutene alternating copolymers
  • Used as derivitizing agent for determination of glutathione disulfide levels in biological samples

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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1-Pyrenebutyric hydrazide for fluorescence, ≥97.0% (T)

Sigma-Aldrich

82669

1-Pyrenebutyric hydrazide

N-tert-Butylmaleimide 97%

Sigma-Aldrich

386421

N-tert-Butylmaleimide

N-Phenylmaleimide 97%

Sigma-Aldrich

P27100

N-Phenylmaleimide

V Guixé
Archives of biochemistry and biophysics, 376(2), 313-319 (2000-04-25)
Modification of Escherichia coli phosphofructokinase-2 (Pfk-2) with N-(1-pyrenil)maleimide results in an enzyme form that is inactive. However, the rate of modification is drastically reduced in the presence of the allosteric effector MgATP. The stoichiometry of the label incorporation was found
Pei-Rong Huang et al.
Molecular biology reports, 39(9), 8899-8905 (2012-06-19)
Telomerase activity is repressed in normal human somatic cells, but is activated in most cancers, suggesting that telomerase may be an important target for cancer therapy. Agents that interact selectively with telomerase are anticipated to exert specific action on cancer
Mateja Mancek-Keber et al.
The Journal of biological chemistry, 284(29), 19493-19500 (2009-05-29)
MD-2 is a part of the Toll-like 4 signaling complex with an indispensable role in activation of the lipopolysaccharide (LPS) signaling pathway and thus a suitable target for the therapeutic inhibition of TLR4 signaling. Elucidation of MD-2 structure provides a
Mauricio Baez et al.
The Biochemical journal, 376(Pt 1), 277-283 (2003-08-21)
Modification of Escherichia coli phosphofructokinase-2 (Pfk-2) with pyrene maleimide (PM) results in a rapid inactivation of the enzyme. The loss of enzyme activity correlates with the incorporation of 2 mol of PM/mol of subunit and the concomitant dissociation of the
Rajam S Mani et al.
Biochemistry, 45(11), 3534-3541 (2006-03-15)
Human deoxycytidine kinase (dCK) phosphorylates both pyrimidine and purine deoxynucleosides, including numerous nucleoside analogue prodrugs. Energy transfer studies of transfer between Trp residues of dCK and the fluorescent probe N-(1-pyrene)maleimide (PM), which specifically labels Cys residues in proteins, were performed.
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