P7443

L-α-fosfatidilcolina

from soybean, ≥99% (TLC), lyophilized powder

• Sinonimo/i: 1,2-diacil-sn-glicero-3-fosfocolina, 3-sn-fosfatidilcolina, L-α-lecitina, Azolectina, PC
• Numero CAS: 8002-43-5
• Beilstein: 5209585
• Numero CE: 232-307-2
• Codice UNSPSC: 12352211
• NACRES: NA.25

Proprietà

• Origine biologica: soybean
• Livello qualitativo: 200
• Saggio: ≥99% (TLC)
• Forma fisica: lyophilized powder
• Gruppo funzionale: phospholipid
• Tipo di lipide: phosphoglycerides
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1; JLPULHDHAOZNQI-ZTIMHPMXSA-N

Descrizione

Descrizione generale

L-α-Phosphatidylcholine (PC) is an asymmetric molecule with glycerol backbone and occurs naturally in lecithin of egg yolk. It is a phospholipid and major choline source in mammalian cells. It is crucial for very low-density lipoprotein secretion in hepatocytes. It is essential for the acetylcholine synthesis functions to nourish the brain. PC plays a crucial role in lipid and lipoprotein metabolism. Deficiencies of enzymes in PC biosynthetic pathway leads to an array of metabolic disorder. Intracellular levels of hepatic PC to phosphatidylethanolamine (PE) ratio contributes to pathophysiology non-alcoholic fatty liver disease (NAFLD). It has anti-inflammatory functionality and is effective in treating inflammatory bowel disease. PC administration therapy is effective for treating benign symmetric lipomatosis.

Applicazioni

L-α-Phosphatidylcholine has been used:

• for liposome preparation
• as a component of stabilizer solution for preparing dispersed curcuminoid submicron particle (CSP)
• as a component of serum free substitute for whole blood cells

Azioni biochim/fisiol

Una dei principali fosfolipidi strutturali del cervello, costituisce il 15% circa dei lipidi totali; localizzata soprattutto nella materia grigia.

Confezionamento

Packaged under Argon

Nota sulla preparazione

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)