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P6628

Sigma-Aldrich

Pilocarpine nitrate salt

≥98% (HPLC)

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About This Item

Formula empirica (notazione di Hill):
C11H16N2O2 · HNO3
Numero CAS:
148-72-1
Peso molecolare:
271.27
Beilstein:
4171406
Numero CE:
205-723-7
Numero MDL:
MFCD00078497
Codice UNSPSC:
12352200
ID PubChem:
57654548
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Attività ottica

[α]25/D +83°, c = 10 in H2O(lit.)

Colore

white

Solubilità

H2O: 100 mg/mL

Stringa SMILE

O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
PRZXEPJJHQYOGF-GNAZCLTHSA-N

Informazioni sul gene

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

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Applicazioni

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

Azioni biochim/fisiol

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.
Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Pittogrammi

Flame over circleSkull and crossbones
GHS03,GHS06

Avvertenze

Danger

Indicazioni di pericolo

H272,H302,H330

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2

Codice della classe di stoccaggio

5.1B - Oxidizing hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats
Nie Z, et al.
American Journal of Respiratory Cell and Molecular Biology, 51(2), 251-261 (2014)
Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures
Andrioli A, et al.
Epilepsia, 50(4), 832-848 (2009)
Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
Manuela Mazzuferi et al.
Annals of neurology, 74(4), 560-568 (2013-05-21)
Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for epilepsy, because single target therapies are unlikely to provide both anticonvulsant and disease-modifying effects. A selection of epilepsy-related gene expression data sets were retrieved
Kevin D Phelan et al.
Molecular pharmacology, 83(2), 429-438 (2012-11-29)
Seizures are the manifestation of highly synchronized burst firing of a large population of cortical neurons. Epileptiform bursts with an underlying plateau potential in neurons are a cellular correlate of seizures. Emerging evidence suggests that the plateau potential is mediated
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