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P4875

D-Penicillamine

98-101%

Sinonimo/i:

3,3-Dimethyl-D-cysteine, 3-Mercapto-D-valine, D-(−)-2-Amino-3-mercapto-3-methylbutanoic acid

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1 g
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44,20 €
5 g
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130,00 €
25 g
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435,00 €

Informazioni su questo articolo

Formula condensata:
(CH3)2C(SH)CH(NH2)CO2H
Numero CAS:
Peso molecolare:
149.21
UNSPSC Code:
51202303
NACRES:
NA.76
PubChem Substance ID:
EC Number:
200-148-8
Beilstein/REAXYS Number:
1722375
MDL number:

44,20 €


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Quality Segment

assay

98-101%

form

powder

mp

210 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

CC(C)(S)[C@@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1

InChI key

VVNCNSJFMMFHPL-VKHMYHEASA-N

Gene Information

mouse ... Oprk1(18387)

General description

D-Penicillamine is derived from the hydrolysis of the corresponding beta-lactam antibiotic.

Application

It is used as an antirheumatic and as a chelating agent in Wilson′s disease. It is used as a copper chelator to form mixed disulfides with cysteine or other sulfide media components. It is used to inactivate protein-1 DNA binding[1] and to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes[2].

Biochem/physiol Actions

Penicillamine is a characteristic degradation product of penicillin type antibiotics. One atom of copper combines with two molecules of penicillamine. Penicillamine reduces excess cystine excretion in cystinuria. This is by disulfide interchange between penicillamine and cystine, which results in formation of a readily excreted penicillamine-cysteine disulfide. Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. Penicillamine lowers IgM rheumatoid factor and depresses T-cell activity.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Questo articolo
196312D9378P1101
D-Penicillamine 98-101%

Sigma-Aldrich

P4875

D-Penicillamine

mode of action

cell wall synthesis | interferes

mode of action

-

mode of action

-

mode of action

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

powder

form

powder

form

powder

form

powder or crystals

assay

98-101%

assay

99%

assay

≥95%

assay

97%

solubility

H2O: 100 mg/mL

solubility

-

solubility

1 M HCl: soluble, ethanol: insoluble

solubility

-

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

storage temp.

-


pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Repr. 2

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Certificati d'analisi (COA)

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Domande

1–2 di 2 domande  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Utile?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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