P2110
Anti-Platelet-Derived Growth Factor Receptor α antibody produced in goat
affinity isolated antibody, lyophilized powder
Sinonimo/i:
Anti-PDGF Rα
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About This Item
Origine biologica
goat
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
lyophilized powder
Reattività contro le specie
human
tecniche
direct ELISA: 0.5-1.0 μg/mL
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 15 μg/mL using human tissue sections
neutralization: suitable
western blot: 0.1-0.2 μg/mL
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... PDGFRA(5156)
Descrizione generale
Blocks cell surface human or mouse PDGF Receptor α mediated biological activity induced by PDGF-AA.
Immunogeno
recombinant soluble human platelet-derived growth factor receptor α expressed in Sf 21 cells.
Azioni biochim/fisiol
Platelet-derived growth factor (PDGF) is a serum growth factor purified from human platelets. The cellular effects of PDGF are mediated by binding to PDGF α- and PDGF β-receptors which leads to activation of downstream signaling via PI3K, STAT and Ras/MAPK. PDGFR stimulates the proliferation of cells of connective tissue and glial cells, survival, differentiation, chemotaxis and wound healing.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Noortje A M Bax et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 238(10), 2658-2669 (2009-08-26)
For the establishment of a fully functional septated heart, addition of myocardium from second heart field-derived structures is important. Platelet-derived growth factors (PDGFs) are known for their role in cardiovascular development. In this study, we aim to elucidate this role
Nynke M S Van Den Akker et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 233(4), 1579-1588 (2005-06-24)
Platelet-derived growth factors (PDGFs) are important in embryonic development. To elucidate their role in avian heart and coronary development, we investigated protein expression patterns of PDGF-A, PDGF-B, and the receptors PDGFR-alpha and PDGFR-beta using immunohistochemistry on sections of pro-epicardial quail-chicken
Johanna Andrae et al.
Genes & development, 22(10), 1276-1312 (2008-05-17)
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-alpha signaling in
Daniel F Bowen-Pope et al.
Arteriosclerosis, thrombosis, and vascular biology, 31(11), 2397-2401 (2011-10-21)
A growth-promoting activity released from activated platelets, the platelet-derived growth factor, was discovered and characterized while the cellular and molecular mechanisms underlying the formation of the lesions of atherosclerosis were being investigated. This review provides a personal account of the
Carl-Henrik Heldin
Upsala journal of medical sciences, 117(2), 83-91 (2012-04-20)
Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and
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