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Merck
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Documenti

O0766

Sigma-Aldrich

ONO-RS-082

≥97% (HPLC)

Sinonimo/i:

2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid, 4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid

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About This Item

Formula empirica (notazione di Hill):
C21H22ClNO3
Numero CAS:
99754-06-0
Peso molecolare:
371.86
Codice UNSPSC:
41106300
NACRES:
NA.77

Saggio

≥97% (HPLC)

Forma fisica

powder

Durata

Do not freeze

Condizioni di stoccaggio

protect from light

Colore

white

Solubilità

DMSO: ≥20 mg/mL

Temperatura di conservazione

room temp

InChI

1S/C21H22ClNO3/c1-2-3-4-5-15-6-8-16(9-7-15)10-13-20(24)23-19-14-17(22)11-12-18(19)21(25)26/h6-14H,2-5H2,1H3,(H,23,24)(H,25,26)/b13-10+
MDVFITMPFHDRBZ-JLHYYAGUSA-N

Azioni biochim/fisiol

ONO-RS-082 is a reversible phospholipase A2 inhibitor.

Caratteristiche e vantaggi

This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Environment
GHS09

Avvertenze

Warning

Indicazioni di pericolo

H410

Consigli di prudenza

P273 - P391 - P501

Classi di pericolo

Aquatic Acute 1 - Aquatic Chronic 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Y Sugita et al.
European journal of pharmacology, 365(1), 77-89 (1999-02-13)
In order to examine some possibly misleading conclusions of the pharmacological analysis of the signal transduction pathways of gastric acid secretion, we evaluated various agents including inhibitors of protein kinase C, cyclic AMP-dependent protein kinase, phospholipase C, phospholipase A2, lipoxygenase
K L Byron
Circulation research, 78(5), 813-820 (1996-05-01)
[Arg8]-vasopressin (AVP) is both a potent vasoconstrictor and a mitogen for vascular smooth muscle cells. AVP binds to a single class of receptors (V1a) in the A7r5 rat aortic smooth muscle cell line (Kd approximately 2 nmol/L). Stimulation of these
T Takeuchi et al.
Japanese journal of pharmacology, 87(4), 309-317 (2002-02-07)
The origin of Ca2+ necessary for carbachol (CCh)-induced contraction of longitudinal muscle of the proximal colon of rats was studied. CCh induced contraction of the muscle consisting of two phases, phasic and tonic phases, with a concomitant biphasic increase in
L Domínguez et al.
International journal of andrology, 19(4), 248-252 (1996-08-01)
Phospholipase A2 (PLA2, EC 3.1.1.4) is involved in the cascade of signalling events leading to the acrosome reaction in human spermatozoa. In order to study the role of PLA2 in the acrosome reaction triggered by GTP gamma S, a non-hydrolizable
H Nishino et al.
The American journal of physiology, 274(3 Pt 1), G525-G534 (1998-04-08)
We investigated the structural requirements for bombesin (BB)-like peptides to stimulate amylase secretion in rat pancreatic acini and examined the responsible intracellular signal transduction pathways. The tetradecapeptide BB-(1-14) was a full agonist, whereas the heptapeptide BB-(8-14) did not evoke amylase
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Articoli

Phospholipase A2

Phospholipase A2 (PLA2) enzymes hydrolyze glycerophospholipids, yielding arachidonic acid; inhibition targets eicosanoid biosynthesis.

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