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Merck
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Documenti fondamentali

O0266

Sigma-Aldrich

Obestatin mouse, rat

synthetic

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About This Item

Formula empirica (notazione di Hill):
C114H174N34O31
Numero CAS:
Peso molecolare:
2516.81
Numero MDL:
Codice UNSPSC:
51111800
ID PubChem:
NACRES:
NA.32
Origine biologica:
synthetic
Stato:
lyophilized powder
Saggio:
≥97% (HPLC)

Origine biologica

synthetic

Saggio

≥97% (HPLC)

Stato

lyophilized powder

Colore

white

Solubilità

deionized water: 0.5-1 mg/mL

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc3ccccc3)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc5c[nH]cn5)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O

InChI

1S/C114H174N34O31/c1-12-60(8)93(146-90(157)54-128-111(177)92(59(6)7)147-109(175)81(50-91(158)159)143-108(174)78(46-65-25-17-14-18-26-65)144-110(176)83-29-22-42-148(83)113(179)63(11)132-105(171)80(49-87(120)154)139-97(163)69(116)45-64-23-15-13-16-24-64)112(178)137-71(27-19-20-40-115)101(167)140-76(44-58(4)5)106(172)145-82(55-149)99(165)127-52-88(155)130-61(9)95(161)134-72(34-37-84(117)151)103(169)141-77(47-66-30-32-68(150)33-31-66)107(173)136-73(35-38-85(118)152)102(168)135-74(36-39-86(119)153)104(170)142-79(48-67-51-124-56-129-67)98(164)126-53-89(156)133-70(28-21-41-125-114(122)123)100(166)131-62(10)96(162)138-75(94(121)160)43-57(2)3/h13-18,23-26,30-33,51,56-63,69-83,92-93,149-150H,12,19-22,27-29,34-50,52-55,115-116H2,1-11H3,(H2,117,151)(H2,118,152)(H2,119,153)(H2,120,154)(H2,121,160)(H,124,129)(H,126,164)(H,127,165)(H,128,177)(H,130,155)(H,131,166)(H,132,171)(H,133,156)(H,134,161)(H,135,168)(H,136,173)(H,137,178)(H,138,162)(H,139,163)(H,140,167)(H,141,169)(H,142,170)(H,143,174)(H,144,176)(H,145,172)(H,146,157)(H,147,175)(H,158,159)(H4,122,123,125)/t60-,61-,62-,63-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,92-,93-/m0/s1
OJSXICLEROKMBP-FFUDWAICSA-N

Informazioni sul gene

mouse ... Ghrl(58991)
rat ... Ghrl(59301)

Amino Acid Sequence

Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2

Descrizione generale

Obestatin is a 23 amino acid bioactive peptide encoded by the ghrelin gene.

Applicazioni

Obestatin has been used to study its effect on serum glucose and enzymatic parameters in rats and used to investigate its effect on plasma acyl-ghrelin and body weight in wistar rat.

Azioni biochim/fisiol

Obestatin opposes the action of circulating appetite-inducing hormone-ghrelin and plays a vital role in weight regulation via hindering food intake, jejunal contraction and reducing the body weight. Obestatin mediates its activity by interacting with the G-protein coupled receptor 39 (GPR-39).
Obestatin, an obesity peptide, along with Ghrelin peptides are derived from the same prepropeptide, Ghrelin. In contrast to Ghrelin, Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents.

Stato fisico

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

Altre note

Lyophilized from 0.1% TFA in H2O

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Eman F Khaleel et al.
Archives of physiology and biochemistry, 125(1), 64-78 (2018-02-13)
This study investigated the ameliorative and protective effects of long-term obestatin administration (80 nmol/kg/ intraperitoneal injection (i.p.)) on the pathogenesis of high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD) in rats. Rats (n = 8/group) were divided as control, NAFLD, NAFLD + Simvastatin, NAFLD + obestatin
Obestatin does not activate orphan G protein-coupled receptor GPR39.
Lauwers E
Biochemical and Biophysical Research Communications, 351(1), 21-25 (2006)
Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats.
Wang J
Endocrine, 33(1), 77-83 (2008)
Effect of Peripheral Obestatin Infusion on Serum Glucose and some Enzymatic Parameters in rats
Rad M N
Advances in Bioresearch, 7 (3), 38-41 (2016)
Effects of obestatin on energy balance and growth hormone secretion in rodents.
Nogueiras R
Endocrinology, 148(1), 21-26 (2007)

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