N3136

Naltrexone hydrochloride

≥99% (HPLC), powder, opioid receptor antagonist

• Sinonimo/i: Naltrexone HCl
• Formula empirica (notazione di Hill): C₂₀H₂₃NO₄ · HCl
• Numero CAS: 16676-29-2
• Peso molecolare: 377.86
• NACRES: NA.77
• PubChem Substance ID: 24278051
• UNSPSC Code: 12352200
• EC Number: 240-723-0
• MDL number: MFCD00069324
• Beilstein/REAXYS Number: 3580333
• Form: powder

Proprietà

• Nome del prodotto: Naltrexone hydrochloride,
• form: powder
• Quality Segment: 100
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
• InChI: 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
• InChI key: RHBRMCOKKKZVRY-ITLPAZOVSA-N
• Gene Information: human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Descrizione

Application

Naltrexone hydrochloride has been used:

• as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
• to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
• in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Parola di avvertenza: Warning
• Codici di pericolo: H302
• Avvertenze di sicurezza: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable
• DPI (dispositivi di protezione individuale): dust mask type N95 (US), Eyeshields, Gloves