N3136

Naltrexone hydrochloride

≥99% (HPLC), powder, opioid receptor antagonist

• Sinonimo/i: Naltrexone HCl
• Formula empirica (notazione di Hill): C₂₀H₂₃NO₄ · HCl
• Numero CAS: 16676-29-2
• Peso molecolare: 377.86
• Beilstein: 3580333
• Numero CE: 240-723-0
• Numero MDL: MFCD00069324
• Codice UNSPSC: 12352200
• ID PubChem: 24278051
• NACRES: NA.77

Proprietà

• Nome del prodotto: Naltrexone hydrochloride,
• Stato: powder
• Ideatore: Novartis
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
• InChI: 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1; RHBRMCOKKKZVRY-ITLPAZOVSA-N
• Informazioni sul gene: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

Descrizione

Applicazioni

Naltrexone hydrochloride has been used:

• as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model[1]
• to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model[2]
• in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22[3]

Azioni biochim/fisiol

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Caratteristiche e vantaggi

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves