N161
NPC-15437 dihydrochloride hydrate
≥97% (NMR), powder
Sinonimo/i:
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide dihydrochloride hydrate
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Informazioni su questo articolo
Formula empirica (notazione di Hill):
C25H50N4O2 · 2HCl · xH2O
Numero CAS:
Peso molecolare:
511.61 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (NMR)
Form:
powder
Storage condition:
desiccated
Servizio Tecnico
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Permettici di aiutartiassay
≥97% (NMR)
form
powder
storage condition
desiccated
color
white
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@@H](N)CCCCN
InChI
1S/C25H50N4O2.2ClH/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26;;/h22-23H,2-21,26-27H2,1H3,(H,28,31);2*1H/t22?,23-;;/m0../s1
InChI key
RISSBZWRJRRXTD-OLBPYZPGSA-N
Application
NPC-15437 dihydrochloride hydrate has been used as a protein kinase C (PKC) inhibitor:
- to test its blocking effect on nicotine-seeking behavior in mice in drug-paired cues
- along with cocaine to test its effect on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in mice
- to study its effect on PKC signaling in object recognition memory studies
Biochem/physiol Actions
NPC 15437 is also reported to be a P-glycoprotein (Pgp) modulator.
Selective protein kinase C inhibitor.
Features and Benefits
This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Classe di stoccaggio
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.
J P Sullivan et al.
FEBS letters, 285(1), 120-123 (1991-07-08)
We recently demonstrated that 2,6,diamino-N-[( 1-(oxotridecyl)-2-piperidinyl]methyl)-hexanamide (NPC 15437) is a selective inhibitor of PKC interacting at the regulatory domain of the enzyme. To further investigate the interaction of NPC 15437 with PKC we expressed a series of cDNAs encoding mutant
E C Sha et al.
Investigational new drugs, 13(4), 285-294 (1996-01-01)
We assessed the effect of the protein kinase C inhibitor 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanami de (NPC 15437) on the action of anthracyclines, epipodophyllotoxins and vinca alkaloids in P-glycoprotein (Pgp)-expressing CH(R)C5 hamster ovary and MCF-7/Adria(R) human breast cancer cells. Flow microfluorimetry revealed that treatment
I Peraile et al.
British journal of pharmacology, 159(1), 201-211 (2009-12-18)
3,4-Methylenedioxymethamphetamine (MDMA) and cocaine are two widely abused psychostimulant drugs targeting the dopamine transporter (DAT). DAT availability regulates dopamine neurotransmission and uptake of MDMA-derived neurotoxic metabolites. We aimed to determine the effect of cocaine pre-exposure on the acute and long-term
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| N161-25MG | 04061832272566 |
| N161-5MG | 04061832449029 |