M4565
Matrix Metalloproteinase-7 human
~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution
Sinonimo/i:
MMP-7, Matrilysin-1
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| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
10 μg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 514,00 € |
Informazioni su questo articolo
Specific activity:
5,000 units/mg protein
Recombinant:
expressed in E. coli
Concentration:
~0.1 mg/mL
514,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Servizio Tecnico
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Permettici di aiutartirecombinant
expressed in E. coli
Quality Segment
form
buffered aqueous solution
specific activity
5,000 units/mg protein
mol wt
20 kDa
concentration
~0.1 mg/mL
UniProt accession no.
relevant disease(s)
cancer
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MMP7(4316)
General description
Matrix metalloproteinase-7 (MMP7) also referred to as matrilysin is encoded by the gene mapped to human chromosome 11q21-q22. MMP7 is a smallest member of MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells.[1]
Application
Matrix metalloproteinase-7 (MMP7) human has been used in in silico analysis of MMP-7 proteolysis of perlecan.[2]
Biochem/physiol Actions
Matrix metalloproteinase-7 (MMP-7) catalyzes the cleavage of extracellular matrix (ECM) proteins such as proteoglycans, fibronectin, entactin, laminin, collagen III/ IV/ V/ IX/ X/ XI, type I/ II/ IV/ V gelatins, and elastin.[1] Matrix metalloproteinase-7 facilitates initial stages of tumor progression. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. Overexpression of MMP7 is observed in various human cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Increased expression of MMP7 is also associated with pathogenesis of demyelinating multiple sclerosis (MS) lesions. Both in silico and in vitro studies show that MMP7 degrades glycosylated and basement membrane bound perlecan and plays a vital role in prostate cancer cell invasion.[2]
Physical form
Solution in 10 mM HEPES, 5 mM CaCl2, 150 mM NaCl
Analysis Note
One unit of enzyme activity is defined as the digestion of 1 μg of azocoll/min. at pH 7.5 and 37 °C.
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Questo articolo | |||
|---|---|---|---|
| Gene Information human ... MMP7(4316) | Gene Information human ... MMP7(4316) | Gene Information human ... MMP7(4316) | Gene Information human ... MMP1(4312) |
| specific activity 5,000 units/mg protein | specific activity - | specific activity - | specific activity - |
| recombinant expressed in E. coli | recombinant - | recombinant - | recombinant expressed in NSO cells |
| form buffered aqueous solution | form buffered aqueous solution | form buffered aqueous solution | form buffered aqueous solution |
| concentration ~0.1 mg/mL | concentration - | concentration ~1 mg/mL | concentration - |
| mol wt 20 kDa | mol wt antigen 29.7 kDa | mol wt antigen 29 kDa | mol wt apparent mol wt 52-55 kDa |
flash_point_f
Not applicable
flash_point_c
Not applicable
wgk
WGK 1
Classe di stoccaggio
12 - Non Combustible Liquids
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