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Merck
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M3281

Sigma-Aldrich

α-Methyl-DL-tyrosine methyl ester hydrochloride

≥95% (HPLC)

Sinonimo/i:

α-MT methyl ester hydrochloride, 2-Methyl-4-hydroxy-DL-phenylalanine methyl ester hydrochloride, AMPT methyl ester hydrochloride

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About This Item

Formula condensata:
4-(HO)C6H4CH2C(CH3)(NH2)CO2CH3 · HCl
Numero CAS:
7361-31-1
Peso molecolare:
245.70
Beilstein:
5163031
Numero CE:
230-900-0
Numero MDL:
MFCD00012606
Codice UNSPSC:
12352108
ID PubChem:
24278548
NACRES:
NA.32

Saggio

≥95% (HPLC)

Punto di fusione

192 °C (dec.) (lit.)

Solubilità

DMSO: ≥20 mg/mL, clear, colorless to faintly yellow

Temperatura di conservazione

−20°C

Stringa SMILE

Cl[H].COC(=O)C(C)(N)Cc1ccc(O)cc1

InChI

1S/C11H15NO3.ClH/c1-11(12,10(14)15-2)7-8-3-5-9(13)6-4-8;/h3-6,13H,7,12H2,1-2H3;1H
OOVDEPZODSXAMU-UHFFFAOYSA-N

Informazioni sul gene

human ... TH(7054)

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Applicazioni

α-Methyl-DL-tyrosine methyl ester hydrochloride has been used to evaluate norepinephrine turnover.

Azioni biochim/fisiol

α-Methyl-DL-tyrosine (α-MT) prevents hyperactivity, sniffing-licking-gnawing syndrome, anorexia and ameliorates certain effects of amphetamine. It inhibits dopamine production and prevents apoptosis stimulated by mutant α-synuclein.
Tyrosine hydroxylase inhibitor.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Journal of Pharmacology and Experimental Therapeutics, 151(3), 339-352 (1966)
Central sympathetic innervations to visceral and subcutaneous white adipose tissue
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J J Liaw et al.
Brain research. Molecular brain research, 13(3), 231-238 (1992-04-01)
Temporal changes in tyrosine hydroxylase (TH) mRNA levels in medullary A1 and A2 neurons and locus coeruleus (LC) cells were studied 6, 12 and 24 h following orchidectomy in rats. Brains from intact controls and sham castrated rats also were
Y Maruyama et al.
Arzneimittel-Forschung, 41(10), 1022-1026 (1991-10-01)
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E Sundström et al.
Brain research, 528(2), 181-188 (1990-10-01)
The long-term effect of the parkinsonism inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on pre- and postsynaptic structures of the nigrostriatal and mesolimbic dopamine (DA) system in adult C57BL/6 mice (2 x 40 mg/kg s.c.) was investigated using neurochemical and behavioral methods. It
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