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M3142

Sigma-Aldrich

Meperidine hydrochloride

Sinonimo/i:

1-Methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester hydrochloride, Pethidine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C15H21NO2 · HCl
Numero CAS:
50-13-5
Peso molecolare:
283.79
Numero CE:
200-013-3
Numero MDL:
MFCD00058210
Codice UNSPSC:
41116107
ID PubChem:
24896799
NACRES:
NA.77

Controllo stupefacenti

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

Ideatore

Sanofi Aventis

Stringa SMILE

Cl[H].CCOC(=O)C1(CCN(C)CC1)c2ccccc2

InChI

1S/C15H21NO2.ClH/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13;/h4-8H,3,9-12H2,1-2H3;1H
WCNLCIJMFAJCPX-UHFFFAOYSA-N

Informazioni sul gene

human ... OPRM1(4988)

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Azioni biochim/fisiol

Phenylpiperidine analgesic; sedative; μ opioid receptor agonist with greater κ opioid receptor agonist activity than morphine.

Caratteristiche e vantaggi

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H336

Classi di pericolo

Acute Tox. 3 Oral - STOT SE 3

Organi bersaglio

Central nervous system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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A Alt et al.
The Journal of pharmacology and experimental therapeutics, 286(1), 282-288 (1998-07-10)
The ability of endogenous opioids to activate G proteins was measured in membranes from C6 rat glioma cells stably expressing a cloned rat mu receptor. Peptides representing each of the three known families of endogenous opioids (enkephalins, endorphins and dynorphins)
S E Abram et al.
Anesthesiology, 87(1), 127-134 (1997-07-01)
One measure of an opioid's efficacy is its ability to retain its analgesic effect as the intensity of a noxious stimulus is increased. A few studies have assessed the ability of either spinal or systemic opioids to produce analgesia using
B C Yoburn et al.
Pharmacology, biochemistry, and behavior, 51(2-3), 535-539 (1995-06-01)
The effect of chronic opioid antagonist treatment on the analgesic potency of six opioid agonists was compared to changes in opioid receptor density and the selectivity of each agonist for mu (DAMGO), delta (DPDPE) and kappa (U69,593) opioid receptors. Mice
Christoph Marcus Bucher et al.
Journal of clinical pathology, 66(1), 24-28 (2012-10-30)
The diagnostic and clinical usefulness of a powered bone marrow biopsy device (OnControl()) versus a standard manual device (TRAP Hospital System) was studied. Primary endpoints were biopsy quality and patient pain during the procedure. Fifty patients underwent a total of
PeiWen Zhou et al.
The Journal of surgical research, 188(1), 69-76 (2014-01-07)
Postoperative shivering is a frequent complication of surgery in developing countries and there is no satisfying method to treat it, let alone to cure it. We studied whether intravenous amino acid (AA) infusion can cure postoperative shivering in the postanesthesia care
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