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M2776

Sigma-Aldrich

Methylergonovine maleate salt

≥98% (TLC)

Sinonimo/i:

9,10-Didehydro-N-[(S)-1-(hydroxymethyl)propyl]-6-methylergoline-8β-carboxamide maleate salt, Methergine maleate salt

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About This Item

Formula empirica (notazione di Hill):
C20H25N3O2 · C4H4O4
Numero CAS:
57432-61-8
Peso molecolare:
455.50
Numero CE:
260-734-4
Numero MDL:
MFCD00078588
Codice UNSPSC:
12352200
ID PubChem:
24278543

Saggio

≥98% (TLC)

Colore

white

Solubilità

H2O: 25 mg/mL
0.1 M HCl: soluble
ethanol: slightly soluble

Stringa SMILE

[H]\C(=C(/[H])C(O)=O)C(O)=O.[H][C@@]12Cc3c[nH]c4cccc(C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO)c34

InChI

1S/C20H25N3O2.C4H4O4/c1-3-14(11-24)22-20(25)13-7-16-15-5-4-6-17-19(15)12(9-21-17)8-18(16)23(2)10-13;5-3(6)1-2-4(7)8/h4-7,9,13-14,18,21,24H,3,8,10-11H2,1-2H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t13-,14+,18-;/m1./s1
NOFOWWRHEPHDCY-DAUURJMHSA-N

Informazioni sul gene

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

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Azioni biochim/fisiol

Dopamine antagonist interacts with serotonergic, dopaminergic and α-adrenergic systems.
Ergot alkaloid which interacts with serotonergic, dopaminergic and α-adrenergic systems. Dopamine antagonist.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301 + H311 + H331,H361

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
127H47073
087F0262
043K1258

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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

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Ahmet Yagmur Bas et al.
European journal of pediatrics, 170(5), 633-637 (2010-10-26)
Methylergonovine (MEV) is a semi-synthetic ergot alkaloid used in the prevention and control of postpartum hemorrhage. This report describes 12 newborns born on the same day in a local country hospital in Turkey and developed sepsis-like symptoms and encephalopathy within
Tomoko Ishibashi et al.
Journal of anesthesia, 25(3), 405-408 (2011-03-25)
Neurological deficits associated with methylergometrine have been reported primarily as a result of reversible cerebral vasoconstriction syndromes (RCVS). RCVS are characterized by reversible multifocal vasoconstrictions of the cerebral arteries heralded by acute severe headache with or without neurological deficits. Here
Taro Nonaka et al.
Obstetrics and gynecology, 117(2 Pt 2), 452-455 (2011-01-22)
Uterine arteriovenous malformations are a rare and potentially life-threatening condition. Medical therapy has not been popular because of the propensity for excessive bleeding in the patient. As a result, the effect of gonadotropin-releasing hormone (Gn-RH) agonists on uterine arteriovenous malformations
Kazutoshi Isobe et al.
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 46(12), 1007-1012 (2009-02-07)
A 35-year-old woman underwent endometrial curettage for suspicion of miscarriage. A few minutes after intravenous injection of methylergometrin (0.2 mg) for inducing uterine contraction, blood gas analysis revealed severe hypoxemia. Chest CT showed diffuse ground-glass opacities in both lung fields
Falah Aboukhoudir et al.
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 10(4), 556-561 (2009-02-10)
The aim of this article was to assess whether abnormal dobutamine stress echocardiography (DSE) can be due to a dobutamine-induced coronary spasm in patients with angiographically documented vasospastic coronary arteries. Between January 2004 and April 2008, we prospectively evaluated all
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