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Documenti

H3791

Sigma-Aldrich

Anti-HOXA3 antibody produced in rabbit

~1.0 mL/mL, affinity isolated antibody

Sinonimo/i:

Anti-HOX1, Anti-HOX1E, Anti-Homeobox A3, Anti-MGC10155

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About This Item

Numero MDL:
MFCD02263083
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen ~60 kDa

Reattività contro le specie

human, mouse

Confezionamento

antibody small pack of 25 μL

Concentrazione

~1.0 mL/mL

tecniche

immunoprecipitation (IP): 5-10 μg using lysates of HEK-293T cells expressing human HOXA3
indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human HOXA3
western blot: 2-4 μg/mL using lysates of HEK-293T cells over expressing human HOXA3

N° accesso UniProt

O43365

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... HOXA3(3200)
mouse ... Hoxa3(15400)

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Descrizione generale

Homeobox A3 (HOXA3) transcription factor/protein belongs to the HOX family. The HOXA3 gene is mapped on the human chromosome at 7p15.2.

Specificità

Anti-HOXA3 specifically recognizes HOXA3.

Applicazioni

Anti-HOXA3 antibody produced in rabbit may be used in:
  • proximity ligation assay
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Azioni biochim/fisiol

Disruption of the homeobox A3 (HOXA3) gene results in embryonic lethality, which was rescued by placing HOXD3. HOXA3 gene expression is upregulated during neovascularization as a result of injury indicating that HOXA3 promotes angiogenesis. Mutations of the HOXA3 gene are associated with defects in thymus organogenesis and parathyroid development.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Stoccaggio e stabilità

Store at −20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at −20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation. Discard working dilutions if not used within 12 hours.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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D Su et al.
Developmental biology, 236(2), 316-329 (2001-07-31)
The thymus and parathyroid glands in mice develop from a thymus/parathyroid primordium that forms from the endoderm of the third pharyngeal pouch. We investigated the molecular mechanisms that promote this unique process in which two distinct organs form from a
Maria Fernanda Setúbal Destro Rodrigues et al.
Genomics, 108(5-6), 185-193 (2016-11-09)
Approximately 300 homeobox loci were identified in the euchromatic regions of the human genome, of which 235 are probable functional genes and 65 are likely pseudogenes. Many of these genes play important roles in embryonic development and cell differentiation. Dysregulation
J M Greer et al.
Nature, 403(6770), 661-665 (2000-02-25)
Biological diversity is driven mainly by gene duplication followed by mutation and selection. This divergence in either regulatory or protein-coding sequences can result in quite different biological functions for even closely related genes. This concept is exemplified by the mammalian
Kimberly A Mace et al.
Journal of cell science, 118(Pt 12), 2567-2577 (2005-05-26)
Wound repair requires both the recruitment and coordination of numerous cell types including inflammatory cells, fibroblasts, endothelial and epithelial cells. Each cell type has a distinct set of cell behavior such as formation of granulation tissue and basement membrane, migration
Xiaolong Zheng et al.
iScience, 26(11), 108306-108306 (2023-11-29)
Human pluripotent stem cell (hPSC)-derived neurons have shown promise in treating spinal cord injury (SCI). We previously showed that hPSC-derived dorsal spinal γ-aminobutyric acid (GABA) neurons can alleviate spasticity and promote locomotion in rats with SCI, but their long-term safety
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