GW22681
Anti-MUC1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
Prodotti consigliati
Origine biologica
chicken
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
Reattività contro le specie
human, mouse, rat
Produttore/marchio commerciale
Genway 15-288-22681
tecniche
immunohistochemistry: suitable
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... MUC1(4582)
Descrizione generale
Mucin 1 (MUC1) is a O-glycosylated, membrane bound, transmembrane glycoprotein belonging to the mucin (MUC) gene family. It is expressed on the apical surface of mucosal epithelia in the lung, eye, breast and stomach. It consists of an N-terminal extracellular domain consisting of variable number tandem repeats (MUC1-TR) of 20 amino acids (aa) and a C-terminal domain which includes a 53aa extracellular region, a transmembrane domain (TM) and a 72aa cytoplasmic tail (MUC1CT).
Applicazioni
Anti-MUC1 antibody produced in chicken is suitbale for immunohistochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Azioni biochim/fisiol
Mucin 1, cell surface associated (MUC1), plays an important role in the cell signaling during cancer progression. It carries tumor-associated epitopes and is aberrantly expressed in tumors. MUC1 plays a crucial role in the development, progression of breast cancer and could promote the invasion ability of breast cancer cells. Mutation in the gene may result in progressive chronic kidney failure with a bland urinary sediment.
Stato fisico
Solution in phosphate buffered saline containing 0.02% sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Raccomandato
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Anthony J Bleyer et al.
Clinical journal of the American Society of Nephrology : CJASN, 9(3), 527-535 (2014-02-11)
The genetic cause of medullary cystic kidney disease type 1 was recently identified as a cytosine insertion in the variable number of tandem repeat region of MUC1 encoding mucoprotein-1 (MUC1), a protein that is present in skin, breast, and lung
S J Gendler et al.
The Journal of biological chemistry, 265(25), 15286-15293 (1990-09-05)
Human mammary cells present on the cell surface a polymorphic epithelial mucin (PEM) which is developmentally regulated and aberrantly expressed in tumors. PEM carries tumor-associated epitopes recognized by the monoclonal antibodies HMFG-1, HMFG-2, and SM-3. Previously isolated partial cDNA clones
M Sahraei et al.
Oncogene, 31(47), 4935-4945 (2012-01-24)
Pancreatic ductal adenocarcinoma (PDA) has one of the worst prognoses of all cancers. Mucin 1 (MUC1), a transmembrane mucin glycoprotein, is a key modulator of several signaling pathways that affect oncogenesis, motility and metastasis. Its expression is known to be
Lili Zhang et al.
The Journal of pathology, 234(1), 60-73 (2014-05-20)
Cigarette smoke increases the risk of lung cancer by 20-fold and accounts for 87% of lung cancer deaths. In the normal airway, heavily O-glycosylated mucin-1 (MUC1) and adherens junctions (AJs) establish a structural barrier that protects the airway from infectious
Ya-Wen Wang et al.
Journal of cancer research and clinical oncology, 140(8), 1271-1281 (2014-05-03)
Increasing evidences demonstrate that CD227 plays a crucial role in the development and progression of breast cancer. However, the function of CD227 in breast carcinoma was still controversial and the investigation on CD227 in Asian race was scarce. To investigate
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