F3554
Anti-Frizzled-10 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinonimo/i:
Anti-FZD10
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About This Item
Numero MDL:
Codice UNSPSC:
12352203
Origine biologica
rabbit
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
Reattività contro le specie
human
tecniche
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3 μg/mL using human kidney, cortex
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... FZD10(11211)
mouse ... Fzd10(93897)
Immunogeno
synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-10, conjugated to KLH. The immunizing peptide has 100% homology with the mouse gene.
Applicazioni
Anti-Frizzled-10 antibody is suitable for immunohistochemistry study (formalin-fixed, paraffin-embedded sections) at a concentration of 3μg/mL using human kidney, cortex.
Azioni biochim/fisiol
Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In humans, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. FZD10, a cell-surface receptor molecules in the Wnt pathway, is expressed during development in embryonic limbs, neural tube, and central nervous system and mediates Wnt signaling. It was reported that FZD10 plays a critical role in the metastasis of synovial sarcoma. Mechanistically, it facilitates the activation of Dvl-Rac1-JNK axis of planar cell polarity (PCP) signaling, with no effect on nuclear β-catenin accumulation and Tcf/Lef reporter activity.
Stato fisico
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
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Satoshi Nagayama et al.
Oncogene, 24(41), 6201-6212 (2005-07-12)
Genome-wide expression profiling revealed overexpression of the gene encoding frizzled homologue 10 (FZD 10), a cell-surface receptor for molecules in the Wnt pathway, as a potential contributor to synovial sarcomas (SS). Northern blotting and immunohistochemical staining confirmed that expression levels
Yingqun Wang
Molecular cancer therapeutics, 8(8), 2103-2109 (2009-08-13)
The evolutionarily conserved and developmentally important Wnt signaling pathway has traditionally been regarded as a critical player in tumorigenesis through the canonical Wnt/beta-catenin cascade. Nevertheless, accumulating evidence based on recent research has revealed the previously unacknowledged role of noncanonical Wnt/planar
Edlaine Linares et al.
Chemical research in toxicology, 37(7), 1129-1138 (2024-06-25)
Peroxymonocarbonate (HCO4-/HOOCO2-) is produced by the reversible reaction of CO2/HCO3- with H2O2 (K = 0.33 M-1, pH 7.0). Although produced in low yields at physiological pHs and H2O2 and CO2/HCO3- concentrations, HCO4- oxidizes most nucleophiles with rate constants 10 to
Koji Ueno et al.
International journal of cancer, 132(8), 1731-1740 (2012-07-27)
Wnt signaling pathways play important roles in tumorigenesis and are initiated by binding of Wnt to various receptors including frizzleds (FZDs). FZDs are one of several families of receptors comprised of FZD/LRP/ROR2/RYK in the Wnt signaling pathway. Expression of some
H Kirikoshi et al.
International journal of oncology, 19(4), 767-771 (2001-09-20)
Frizzled (FZD) genes encode seven-transmembrane type WNT receptors, which are implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, and FZD10. Here, we investigated expression profiles of all members of
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