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F0267

Sigma-Aldrich

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys

≥97% (HPLC)

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About This Item

Formula empirica (notazione di Hill):
C43H65N7O9
Numero CAS:
71901-21-8
Peso molecolare:
824.02
Numero MDL:
MFCD00076348
Codice UNSPSC:
12352200
ID PubChem:
24894717

Saggio

≥97% (HPLC)

Temperatura di conservazione

−20°C

Stringa SMILE

CCCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCC)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(CCCCN)C(O)=O

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Azioni biochim/fisiol

Potent chemoattractant for human neutrophils.
Radioiodinated molecule has full biological activity.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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L A Sklar et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(12), 7540-7544 (1981-12-01)
Antifluorescein antibody molecules were used to interrupt the stimulation of neutrophils by a fluoresceinated chemotactic peptide. From the results we construct a semiquantitative relationship among ligand-receptor interaction, the time course of cell triggering and response, and aspects of cellular adaptation.
V Radhika et al.
American journal of hematology, 52(3), 155-164 (1996-07-01)
Binding of chemoattractant to polymorphonuclear leukocytes (PMNL) triggers a series of events like polymerization of actin and tubulin, orientation of cells, chemotaxis, increase in fluid pinocytosis and phagocytosis, and stimulation of microbicidal pathways which includes lysosomal degranulation and generation of
V Niggli et al.
European journal of pharmacology, 335(1), 43-52 (1997-11-26)
To define a possible role of the enzyme phosphatidylinositol 3-kinase (PI 3-kinase) in motile functions of neutrophils, we have used a potent inhibitor of this enzyme, [1S-(1alpha,6b alpha,9a beta,11alpha,11bbeta)]-1-(acetyloxy)-1,6b,7,8,9a,10,11 ,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno [4,5-h]-2-benzopyran-3,6,9-trione (wortmannin). Wortmannin markedly attenuated chemotactic peptide-induced development of polarity
J Niedel
The Journal of biological chemistry, 256(17), 9295-9299 (1981-09-10)
The formyl peptide chemotactic receptor has been solubilized by digitonin treatment of purified human neutrophil membranes. Of several potential assay methods tested for their ability to separate receptor-bound from free ligand, only gel filtration through an acrylamide cross-linked agarose matrix
G Vaidyanathan et al.
Nuclear medicine and biology, 22(6), 759-764 (1995-08-01)
A potent chemotactic peptide, formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine was derivatized by reaction with N-succinimidyl 4-fluorobenzoate. This derivatized peptide bound to human polymorphonuclear leukocytes in vitro and exhibited biological activity in a superoxide production assay. Peptide labeling using N-succinimidyl 4-[18F]fluorobenzoate was accomplished in reasonable
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