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E9505

β-Estradiol 3-sulfate sodium salt

≥93%

Sinonimo/i:

1,3,5(10)-Estratriene-3,17β-diol 3-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-sulfate

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Informazioni su questo articolo

Formula condensata:
C18H23O5SNa
Numero CAS:
Peso molecolare:
374.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥93%
Form:
powder
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sterility

non-sterile

Quality Segment

assay

≥93%

form

powder

contains

~70% N-methyl-D-glucamine as stabilizer

solubility

methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,17+,18+;;/m1../s1

InChI key

PYPVMTJYMKHIST-LBARCDFESA-N

General description

β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.

Application

β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.

Biochem/physiol Actions

β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.

Packaging

Package size based on steroid content

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Questo articolo
E2128E1127E2127
assay

≥93%

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

room temp

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless

solubility

0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

water: 10 mg/mL, clear to slightly hazy

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient


pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges



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Certificati d'analisi (COA)

Lot/Batch Number

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Domande

  1. The description of the product says that it contains 70 % N-methyl-D-glucamine as a stabilizer. Does this mean that 1.0 mg of the powder contains 0.3 mg of β-Estradiol 3-sulfate and that I need to weigh in 3.33 mg of the powder to get 1 mg of substance?

    1 risposta
    1. This understanding is correct, however, the stabilizer content is approximately 70%. The lot-specific Certificate of Analysis will provide the exact stabilizer content, which can then be used to calculate the amount of β-Estradiol 3-Sulfate.
      https://www.sigmaaldrich.com/product/sigma/e9505#product-documentation

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