E9406

Epirubicin hydrochloride

≥90% (HPLC)

• Sinonimo/i: 4′-Epidoxorubicin hydrochloride, Epidoxorubicin hydrochloride
• Formula empirica (notazione di Hill): C₂₇H₂₉NO₁₁ · HCl
• Numero CAS: 56390-09-1
• Peso molecolare: 579.98
• NACRES: NA.85
• PubChem Substance ID: 329799084
• UNSPSC Code: 51102829
• EC Number: 260-145-2
• MDL number: MFCD00941448

Proprietà

• biological source: synthetic
• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: powder
• color: red to deep red
• solubility: H₂O: soluble
• antibiotic activity spectrum: neoplastics
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: −20°C
• SMILES string: Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1
• InChI key: MWWSFMDVAYGXBV-FGBSZODSSA-N

Descrizione

Application

Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.

Biochem/physiol Actions

Cell-permeable anthracycline antitumor antibiotic. Antineoplastic. A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II.

Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Parola di avvertenza: Danger
• Codici di pericolo: H302,H340,H350,H360
• Avvertenze di sicurezza: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• DPI (dispositivi di protezione individuale): dust mask type N95 (US), Eyeshields, Gloves