E8651
Anti-E2F3 antibody ,Mouse monoclonal
clone PG30, purified from hybridoma cell culture
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About This Item
Prodotti consigliati
Origine biologica
mouse
Coniugato
unconjugated
Forma dell’anticorpo
purified from hybridoma cell culture
Tipo di anticorpo
primary antibodies
Clone
PG30, monoclonal
Forma fisica
buffered aqueous solution
PM
antigen 57 kDa
Reattività contro le specie
human
Concentrazione
~2 mg/mL
tecniche
immunoprecipitation (IP): suitable using denatured E2F3
microarray: suitable
western blot: 4-8 μg/mL using transfected 293T cells expressing E2F3
Isotipo
IgG2a
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... E2F3(1871)
Descrizione generale
Monoclonal Anti-E2F3 (mouse IgG2a isotype) is derived from the PG30 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human E2F Transcription Factor 3 (E2F3) protein. Transcription factor E2F3 is a DNA-binding protein of ~57 kDa encoded by the E2F3 gene in humans. It belongs to E2F transcription factor family of proteins that bind to the sequence TTTCGCGC.
Immunogeno
recombinant human E2F3.
Applicazioni
Monoclonal Anti-E2F3 antibody produced in mouse has been used for the following applications:
- immunoprecipitation using denatured E2F3
- western blotting at a concentration of 4-8μg/mL using transfected 293T cells expressing E2F3
- electrophoretic mobility shift assay (EMSA).
Azioni biochim/fisiol
Transcription factor E2F3 is involved in the regulation of cell cycle. E2F3 helps in the regulation of the expression of a number of genes that are important in cell proliferation. It is a oncogene with strong proliferative potential and is involved in many processes. E2F3 plays an important role in the development of several types of cancer. Overexpression of E2F3 may be associated with hepatocellular carcinoma (HCC). It plays an important role in controlling cell cycle progression and proliferation. E2F3 is frequently expressed in pediatric Wilms′ tumors and may be associated with the same.
Stato fisico
Solution in phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
Nota sulla preparazione
Purified from culture supernatant of hybridoma cells grown in a bioreactor.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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Qun An et al.
Journal of pediatric surgery, 48(11), 2187-2193 (2013-11-12)
The transcription factor E2F3 plays an important role in controlling cell cycle progression and proliferation, and is overexpressed in various human cancers. The present study was undertaken to examine the expression of E2F3 and investigate its relevance in clinical and
Cloning and characterization of human DP2, a novel dimerization partner of E2F.
Zhang, et al.
Oncogene, 10(11), 2085-2093 (1995)
Qiang Wang et al.
Immunity, inflammation and disease, 11(8), e987-e987 (2023-08-30)
E2F transcription factors are well-recognized oncogenic molecules, and their correlation with immune cell infiltration has recently been reported. This work studies the impacts and mechanism of E2F transcription factor 3 (E2F3) in the growth and tumor microenvironment (TME) of nasopharyngeal
Xiaoyun Zeng et al.
Oncology reports, 31(3), 1139-1146 (2014-01-10)
E2F transcription factor 3 (E2F3), a member of the E2F transcription factor family and a member of the genes involved in the regulation of cell cycle, is an oncogene with strong proliferative potential. E2F3 is involved in many processes and
J A Lees et al.
Molecular and cellular biology, 13(12), 7813-7825 (1993-12-01)
E2F is a transcription factor that helps regulate the expression of a number of genes that are important in cell proliferation. Recently, several laboratories have isolated a cDNA clone that encodes an E2F-like protein, known as E2F-1. Subsequent characterization of
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