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D7815

Sigma-Aldrich

R(−)-Denopamine

≥98% (HPLC), powder

Sinonimo/i:

(−)-α-(3,4-Dimethoxyphenethylaminomethyl)-4-hydroxy­benzyl­alcohol

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About This Item

Formula empirica (notazione di Hill):
C18H23NO4
Numero CAS:
71771-90-9
Peso molecolare:
317.38
Numero MDL:
MFCD00867122
Codice UNSPSC:
12352116
ID PubChem:
24278687
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white

Solubilità

DMSO: 10 mg/mL, clear
H2O: insoluble

Temperatura di conservazione

2-8°C

Stringa SMILE

COc1ccc(CCNC[C@H](O)c2ccc(O)cc2)cc1OC

InChI

1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
VHSBBVZJABQOSG-INIZCTEOSA-N

Informazioni sul gene

human ... ADRB1(153)

Applicazioni

R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).

Azioni biochim/fisiol

Denopamine is a cardiotonic drug.
β1-adrenoceptor agonist.

Caratteristiche e vantaggi

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Light sensitive.

Pittogrammi

Health hazard
GHS08

Avvertenze

Warning

Indicazioni di pericolo

H361

Consigli di prudenza

P281

Classi di pericolo

Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Weak arrhythmogenic property of the new cardiotonic agent denopamine in dogs: comparison with catecholamines
NARITA H, et al.
Japanese Journal of Pharmacology, 41(3), 335-344 (1986)
H Kurosawa et al.
Japanese journal of pharmacology, 72(4), 325-333 (1996-12-01)
Influence of cardiotonic agents on the prognosis of heart failure depends on the individual therapeutic agents, and favorable and unfavorable effects of these agents have been reported in clinical trials. We studied the effect of the cardiotonic agent denopamine on
Barry M Trost et al.
Organic letters, 4(16), 2621-2623 (2002-08-03)
[reaction: see text] Syntheses of variously modified ligands for the dinuclear zinc catalysts for the asymmetric aldol and nitroaldol (Henry) reactions are reported. Catalytic enantioselective nitroaldol reactions promoted by these modified ligands led to efficient syntheses of the beta-receptor agonists
N Ohashi et al.
Journal of pharmaceutical and biomedical analysis, 18(3), 325-334 (1999-03-30)
The usefulness of the hydrogen-deuterium (H-D) exchange method in the study of drug metabolism was investigated. Metabolite samples of denopamine and promethazine prepared in vitro were introduced to a triple stage quadrupole tandem mass spectrometer via a high performance liquid
Ruduwaan Salie et al.
Basic research in cardiology, 107(5), 281-281 (2012-07-17)
The aim of this study was to investigate the mechanism of beta-adrenergic preconditioning (BPC). The roles of adenosine and its receptor subtypes, the generation of oxygen free radicals (ROS) and activation of the K(ATP) channels as well as the phosphoinositide-3-kinase
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