D5321

D36 hydrate

≥98% (HPLC)

• Sinonimo/i: 5-(2-methoxyphenyl)-1-(2-methylpropyl)-1H-Indole-3-acetamide Hydrate
• Formula empirica (notazione di Hill): C₂₁H₂₄N₂O₂ · xH₂O
• Numero CAS: 1228184-64-2
• Peso molecolare: 336.43 (anhydrous basis)
• Numero MDL: MFCD16875421
• Codice UNSPSC: 51111800
• ID PubChem: 329798803

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to off-white
• Solubilità: DMSO: >10 mg/mL
• Ideatore: GlaxoSmithKline
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O.COc1ccccc1-c2ccc3n(CC(C)C)cc(CC(N)=O)c3c2
• InChI: 1S/C21H24N2O2.H2O/c1-14(2)12-23-13-16(11-21(22)24)18-10-15(8-9-19(18)23)17-6-4-5-7-20(17)25-3;/h4-10,13-14H,11-12H2,1-3H3,(H2,22,24);1H2; ZERKAKHVUQMJPW-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

D36 is an androgen receptor (AR) allosteric antagonist with inverse agonist properties. D36 inhibits both wild-type and agonist-induced AR activity and antagonized AR in a hormone-refractory model.

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable