D3775

Doxylamine succinate salt

• Formula empirica (notazione di Hill): C₁₇H₂₂N₂O · C₄H₆O₄
• Numero CAS: 562-10-7
• Peso molecolare: 388.46
• Numero CE: 209-228-7
• Numero MDL: MFCD00056168
• Codice UNSPSC: 12352116
• ID PubChem: 24278368
• NACRES: NA.77

Proprietà

• Forma fisica: powder
• Livello qualitativo: 200
• Ideatore: Sanofi Aventis
• Stringa SMILE: OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2
• InChI: 1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8); KBAUFVUYFNWQFM-UHFFFAOYSA-N
• Informazioni sul gene: human ... HRH1(3269)

Descrizione

Descrizione generale

Doxylamine belongs to the ethanolaime class of antihistamines and is metabolized by the liver into N-demethyl doxylamine and N,N-didemethyl doxylamine. It is generally available as an over the counter (OTC) drug for allergy and cold symptoms.

Applicazioni

Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.

Doxylamine succinate salt has been used to study the effects of non-teratogenic exposures on morphology and gene expression in human embryonic stem cell aggregates (HESCA)-CSR, under low concentration of retinoic acid in CS medium.

Azioni biochim/fisiol

H₁ histamine receptor antagonist; hypnotic.
Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.
Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.

Caratteristiche e vantaggi

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302 + H312 + H332,H335
• Consigli di prudenza: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Classi di pericolo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves