D0676

Dobutamine hydrochloride

≥98% (TLC), powder, α1, β1 and β2-adrenoceptor agonist

• Sinonimo/i: (±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride
• Formula empirica (notazione di Hill): C₁₈H₂₃NO₃ · HCl
• Numero CAS: 49745-95-1
• Peso molecolare: 337.84
• NACRES: NA.77
• PubChem Substance ID: 24277772
• UNSPSC Code: 12352116
• EC Number: 256-464-1
• MDL number: MFCD00153795
• Assay: ≥98%
• Form: powder

Proprietà

• Nome del prodotto: Dobutamine hydrochloride, ≥98%
• Quality Segment: 200
• assay: ≥98%
• form: powder
• originator: Eli Lilly
• storage temp.: 2-8°C
• SMILES string: Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2
• InChI: 1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
• InChI key: BQKADKWNRWCIJL-UHFFFAOYSA-N
• Gene Information: human ... ADRB1(153), ADRB2(154)

Descrizione

Application

Dobutamine hydrochloride has been used:

• to treat mouse embryonic fibroblasts for cell death analysis
• to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
• as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging

Biochem/physiol Actions

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Parola di avvertenza: Warning
• Codici di pericolo: H302 + H312 + H332,H361fd
• Avvertenze di sicurezza: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• DPI (dispositivi di protezione individuale): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges